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Protein-truncating variants in UQCRC1 are associated with Parkinson’s disease: evidence from half-million people

Xiaoxi Jing
Zongzhi Liu
Yajie Zhao
ResearchOpen Access09 May 2025
npj Parkinson's Disease

Volume: 11, P: 1-5
Human genetic diversity alters off-target outcomes of therapeutic gene editing

CRISPRme is an off-target nomination tool that accounts for human genetic diversity. Ancestry-dependent allele-specific off-target edits can occur with therapies currently in clinical trials, highlighting the importance of genetic variation-aware assessment.

Samuele Cancellieri
Jing Zeng
Luca Pinello
Research15 Dec 2022
Nature Genetics

Volume: 55, P: 34-43
Precise DNA cleavage using CRISPR-SpRYgests

A PAMless CRISPR nuclease is applied for precision DNA cleavage and cloning.

Kathleen A. Christie
Jimmy A. Guo
Benjamin P. Kleinstiver
Research06 Oct 2022
Nature Biotechnology

Volume: 41, P: 409-416

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Protein-truncating variants in UQCRC1 are associated with Parkinson’s disease: evidence from half-million people

Human genetic diversity alters off-target outcomes of therapeutic gene editing

Precise DNA cleavage using CRISPR-SpRYgests

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