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Showing 1–10 of 10 results

Advanced filters: Author: Jieli Lu Clear advanced filters

Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk

Data from two large longitudinal cohorts in China, in which the participants were clustered into five groups based on their metabolic characteristics, show that a signature of microbiome age modulates the risk of cardiovascular disease in metabolically unhealthy individuals.

Tiange Wang
Zhun Shi
Weiqing Wang
Research06 Jun 2024
Nature Medicine

Volume: 30, P: 1722-1731
Transcriptome-wide Mendelian randomization during CD4⁺ T cell activation reveals immune-related drug targets for cardiometabolic diseases

Here, the authors identify genes and drug targets that show immune cell-specific and activation time point-specific effects on type 2 diabetes and coronary heart disease and find strong immune-to-metabolic disease connections.

Xueyan Wu
Hui Ying
Jieli Lu
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome

Male sex is a risk factor for impaired glucose metabolism and type 2 diabetes. Here the authors identify that androgen modulates the gut microbiome, which drives insulin resistance and contributes to sexual dimorphism in glucose metabolism in mice.

Aibo Gao
Junlei Su
Weiqing Wang
ResearchOpen Access06 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Study on the nonfatigue and fatigue states of orchard workers based on electrocardiogram signal analysis

Ruitao Gao
Huachao Yan
Liang Guo
ResearchOpen Access22 Mar 2022
Scientific Reports

Volume: 12, P: 1-17
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals

Yanan Cao
Lin Li
Mengyao Wang
ResearchOpen Access30 Apr 2020
Cell Research

Volume: 30, P: 717-731
BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA

Feiye Zhou
Chunxiang Sheng
Libin Zhou
ResearchOpen Access10 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-12
Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function

Xueyan Wu
Lei Jiang
Jieli Lu
ResearchOpen Access05 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-9
Sodium butyrate potentiates insulin secretion from rat islets at the expense of compromised expression of β cell identity genes

Shushu Wang
Miaomiao Yuan
Libin Zhou
ResearchOpen Access19 Jan 2022
Cell Death & Disease

Volume: 13, P: 1-10
CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity

Linlin Zhang
Chunxiang Sheng
Xiao Wang
ResearchOpen Access12 May 2021
Cell Death & Disease

Volume: 12, P: 1-12
Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population

Jia Xu
Hou Yanan
Chen Yuhong
ResearchOpen Access02 Apr 2019
Scientific Reports

Volume: 9, P: 1-9