Nature Search

Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control

The role of norepinephrine (NE) and acetylcholine (ACh) signaling in the cognitive control of impulsivity remains unclear. Here, the authors reveal that impulse control depends on phase synchrony between NE and ACh dynamics in the prefrontal cortex.

Yuxiang Andy Liu
Yuhan Nong
Qi Wang
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-21
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Kjaerby and Andersen et al. show that norepinephrine (NE) plays profound roles in shaping sleep micro-architecture. NE slowly oscillates during sleep, with NE oscillatory amplitude being a major determinant of spindle-dependent memory consolidation and awakenings.

Celia Kjaerby
Mie Andersen
Maiken Nedergaard
Research07 Jul 2022
Nature Neuroscience

Volume: 25, P: 1059-1070
Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo

Deng et al. expand the toolbox of neurotransmitter sensors with high-sensitivity green and red genetically encoded serotonin sensors. These are suitable for in vivo applications, as demonstrated in a variety of applications in mice.

Fei Deng
Jinxia Wan
Yulong Li
Research05 Mar 2024
Nature Methods

Volume: 21, P: 692-702
Dentate gyrus norepinephrine ramping facilitates aversive contextual processing

Neuromodulatory neural mechanisms behind contextual processing are not fully understood. Here, the authors show how spatiotemporal dynamics of locus coeruleus-norepinephrine release in dentate gyrus modulate contextual discrimination, opening new avenues for treatment of stress-related disorders.

Eric T. Zhang
Grace S. Saglimbeni
Michael R. Bruchas
ResearchOpen Access07 Jan 2025
Nature Communications

Volume: 16, P: 1-12
Spatiotemporal dynamics of noradrenaline during learned behaviour

Noradrenaline-expressing neurons in the locus coeruleus in mouse facilitate task execution and encode reinforcement in learning tasks, via partially modular projections to the cortex.

Vincent Breton-Provencher
Gabrielle T. Drummond
Mriganka Sur
Research01 Jun 2022
Nature

Volume: 606, P: 732-738
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Red and improved green versions of the genetically encoded dopamine sensor GRAB_DA have been developed. These neurotransmitter sensors are used alone or in combination with, for example, calcium sensors in behaving fruit flies and rodents.

Fangmiao Sun
Jingheng Zhou
Yulong Li
Research21 Oct 2020
Nature Methods

Volume: 17, P: 1156-1166
A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

Miao Jing
Peng Zhang
Yulong Li
Research09 Jul 2018
Nature Biotechnology

Volume: 36, P: 726-737
Correction: Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

Bin He
Rui Gao
Quentin Liu
Amendments and CorrectionsOpen Access02 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1
A genetically encoded sensor for measuring serotonin dynamics

The authors develop a genetically encoded GPCR-based sensor to image serotonin dynamics in behaving animals with high specificity, sensitivity and spatiotemporal resolution.

Jinxia Wan
Wanling Peng
Yulong Li
Research05 Apr 2021
Nature Neuroscience

Volume: 24, P: 746-752
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

Bin He
Rui Gao
Quentin Liu
ResearchOpen Access19 Jul 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-19
On conservation of world heritage Beijing-Hangzhou grand canal for enhancing cultural ecosystem services

Yixin Zhang
Zehui Jing
António Candeias
ResearchOpen Access19 Dec 2023
Heritage Science

Volume: 11, P: 1-24

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Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo

Dentate gyrus norepinephrine ramping facilitates aversive contextual processing

Spatiotemporal dynamics of noradrenaline during learned behaviour

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

Correction: Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

A genetically encoded sensor for measuring serotonin dynamics

Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

On conservation of world heritage Beijing-Hangzhou grand canal for enhancing cultural ecosystem services

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