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Showing 1–4 of 4 results

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Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

The potential recovery of the human gut microbiota after an antibiotic treatment, and its effects on our health, are poorly understood. Here, the authors use a mouse model mimicking paediatric antibiotic use to shed new light into these processes.

Yael R. Nobel
Laura M. Cox
Martin J. Blaser
ResearchOpen Access30 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

The Wdfy3gene has been associated with autism spectrum disorders in children. Here, the authors examine two separate mutant alleles of this gene in mice and identify its role in cortical neurogenesis, reproducing pathological changes characteristic of the disorder.

Lori A. Orosco
Adam P. Ross
Konstantinos S Zarbalis
Research08 Sept 2014
Nature Communications

Volume: 5, P: 1-13
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

Pulsed doses of antibiotics increased the incidence of type 1 diabetes in non-obese diabetic (NOD) mice. This was associated with altered gut microbial composition, lipid metabolism, host cholesterol biosynthetic gene expression and Th17 and Treg cell proportions.

Alexandra E. Livanos
Thomas U. Greiner
Martin J. Blaser
Research22 Aug 2016
Nature Microbiology

Volume: 1, P: 1-13
Calorie restriction slows age-related microbiota changes in an Alzheimer’s disease model in female mice

Laura M. Cox
Marissa J. Schafer
Martin J. Blaser
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-14