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Showing 1–7 of 7 results
Advanced filters: Author: Jillian Astarita Clear advanced filters

  • Emerging evidence suggests that the stroma of the tumour microenvironment can shape antitumour immunity and responsiveness to immunotherapy. The stromal cells and the signals they produce that influence tumour-infiltrating leukocytes, as well as the implications for cancer treatment, are reviewed here.

    • Shannon J. Turley
    • Viviana Cremasco
    • Jillian L. Astarita
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 669-682

  • It has been previously shown that combining immune checkpoint inhibitors with TGFβ blockade potentiates anti-tumor immune responses. Here the authors show that, in an immune excluded preclinical tumor model, combining therapeutic anti-PD-L1 with anti-TGFβ treatment promotes expansion and differentiation of stem-cell like CD8 + T cells.

    • Alessandra Castiglioni
    • Yagai Yang
    • Sören Müller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Fibroblastic reticular cells (FRCs) provide structural support and soluble factors necessary for proper lymph node organization and function. Turley and colleagues use scRNA-seq to identify a unique Gremlin1-expressing FRC subset that is found in T cell zones. Grem1+ FRCs support the survival of resident cDCs and are necessary to promote T cell immunity.

    • Varun N. Kapoor
    • Sören Müller
    • Shannon J. Turley
    Research
    Nature Immunology
    Volume: 22, P: 571-585

  • Lymph nodes expand after an inflammatory challenge to accommodate their increased cellularity. Turley and colleagues show that fibroblastic reticular cells regulate this expansion process through the interaction of podoplanin with its receptor CLEC-2 expressed on incoming dendritic cells.

    • Jillian L Astarita
    • Viviana Cremasco
    • Shannon J Turley
    Research
    Nature Immunology
    Volume: 16, P: 75-84

  • In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

    • Sanjeev Mariathasan
    • Shannon J. Turley
    • Thomas Powles
    Research
    Nature
    Volume: 554, P: 544-548

  • During inflammation, the lymph node stromal compartment is shown to accommodate high numbers of infiltrating lymphocytes by relaxing the cytoskeleton of fibroblastic reticular cells, allowing the latter to stretch and the lymph node to expand.

    • Sophie E. Acton
    • Aaron J. Farrugia
    • Caetano Reis e Sousa
    Research
    Nature
    Volume: 514, P: 498-502