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Showing 1–3 of 3 results
Advanced filters: Author: Jim Middelburg Clear advanced filters

  • A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer ‘armoured’ CAR T cells that secrete proinflammatory cytokines directly within a tumour without causing toxicity, leading to prolonged survival in mice.

    • Amanda X. Y. Chen
    • Kah Min Yap
    • Paul A. Beavis
    ResearchOpen Access
    Nature
    Volume: 644, P: 241-251

  • A technique for the site-directed conjugation of antibodies via the small-protein ubiquitin allows for the efficient multivalent conjugation of antibodies and nanobodies to fusions of ubiquitin with molecular or proteinic moieties.

    • Angela F. el Hebieshy
    • Zacharias Wijfjes
    • Ferenc A. Scheeren
    ResearchOpen Access
    Nature Biomedical Engineering
    Volume: 9, P: 1101-1116

  • CD3 bispecific antibodies (bsAbs) have demonstrated promising clinical responses in hematological malignancies but clinical benefit in solid tumors has been limited. Here the authors report that pre-treatment vaccination promotes the infiltration of tumor-(un)related effector CD8 T cells, improving the efficacy of CD3 bsAbs in solid tumors.

    • Jim Middelburg
    • Marjolein Sluijter
    • Thorbald van Hall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15