The mechanism of HBsAg antigen presentation to T cells during liver HBV infection is incompletely understood. Here, the authors show that in mice, intrahepatic type I dendritic cells acquire HBsAg by MHC-I complexes through cross-dressing for CD8+ T cell priming, whereas CD4+ T cell responses rely on MHC-II-dependent antigen presentation by B cells in secondary lymphoid tissues.
- Xiaofang Li
- Wenxuan Sun
- Jianhua Li
