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Showing 1–2 of 2 results
Advanced filters: Author: Jin-hui Ding Clear advanced filters

  • Cholesterol sensing by LYCHOS regulates mTORC1 signaling through GATOR1-Rag GTPase. Here, authors reveal cryo-EM structures of LYCHOS in various states, showing cholesterol binding shifts it from an expanded to a contracted state, exposing a cytosolic element that engages GATOR1.

    • Shang Yu
    • Jin-hui Ding
    • Ling Liang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • This study presents a comprehensive pipeline to profile transmembrane receptors involved in macrophage-driven inflammation in pancreatic islets during the onset of diabetes. The authors identify GPR132 as a mediator of macrophage-driven inflammation and find compounds that reduce inflammation and improve glycaemic control.

    • Jia-Le Wang
    • Xiao-Dong Dou
    • Xiao Yu
    Research
    Nature Metabolism
    Volume: 5, P: 1726-1746