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Structural insights into the mechanism of pancreatic K_ATP channel regulation by nucleotides

K_ATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic K_ATP in both the closed state and the pre-open state. These structures illuminate the mechanism of K_ATP channel regulation by the intracellular nucleotides.

Mengmeng Wang
Jing-Xiang Wu
Lei Chen
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-10
Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

Jun-Li Zhang
Xiao-Jun Zhuo
Sheng-Wei Jin
Research20 Feb 2017
Laboratory Investigation

Volume: 97, P: 543-554

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Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides

Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

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Structural insights into the mechanism of pancreatic K_ATP channel regulation by nucleotides