Nature Search

Photoinduced formal [4 + 2] cycloaddition of two electron-deficient olefins and its application to the synthesis of lucidumone

Electronically mismatched Diels−Alder reaction between two electron-deficient components is synthetically useful and yet underdeveloped. Herein, a photoinduced formal [4 + 2] cycloaddition of enone with a variety of electron-deficient dienes is described.

Zhezhe Xu
Weibo Peng
Anhua Hu
ResearchOpen Access11 Nov 2024
Nature Communications

Volume: 15, P: 1-7
Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma

Multi-omic analysis of 39 samples of treatment-naive and recurrent nasopharyngeal carcinomas highlights the importance of the tumor microenvironment in promoting radioresistance and immune escape.

Rui You
Qunlun Shen
Mingyuan Chen
Research21 Jul 2025
Nature Genetics

Volume: 57, P: 1950-1965
Self-iterative multiple-instance learning enables the prediction of CD4⁺ T cell immunogenic epitopes

ImmuScope, a weakly supervised deep learning model capable of analysing multi- and single-allelic data, is introduced, facilitating interpretable neoantigen discovery and immune escape analysis.

Long-Chen Shen
Yumeng Zhang
Jiangning Song
ResearchOpen Access10 Jul 2025
Nature Machine Intelligence

Volume: 7, P: 1250-1265
Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion

Striatonigral neurons comprise diverse subtypes, yet their specific roles in locomotion regulation are not fully understood. Here, authors demonstrate that the Calb1+ subtype promotes locomotion, while the Kremen1+ subtype terminates ongoing movement by inhibiting the activity of Aldh1a1+ dopaminergic neurons via GABBR1 receptors.

Jie Dong
Lupeng Wang
Huaibin Cai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.

Zhenhua Liu
Nannan Yang
Beisha Tang
ResearchOpen Access17 Jun 2022
Nature Communications

Volume: 13, P: 1-16
The type III effector NopL interacts with GmREM1a and GmNFR5 to promote symbiosis in soybean

This study showed that the type III effector NopL can interact with the Nod factor receptor GmNFR5, and the existence of NopL can promote GmREM1 interacts with GmNFR5, which demonstrates a signaling pathway underlying the symbiosis establishment in soybean.

Chao Ma
Jinhui Wang
Dawei Xin
ResearchOpen Access12 Jul 2024
Nature Communications

Volume: 15, P: 1-16
Nanoparticles for inducing Gaucher disease-like damage in cancer cells

Increased nutrient uptake of cancer cells offers a possible therapeutic target. Here, the authors designed a nanoparticle to deliver phenylboronic-acid-modified cholesterol which reacts in cancer cells to trigger Gaucher disease-like metabolic damage to tumour cells, demonstrating potential application.

Chunyan Yue
Wenjing Lu
Yiqiao Hu
Research13 May 2024
Nature Nanotechnology

Volume: 19, P: 1203-1215
Single-cell RNA sequencing reveals the effects of mental stress on mouse mammary tumors and the tumor microenvironment

Pengfei Liu
Wenjing Ma
Zuoren Yu
ResearchOpen Access16 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-14
Aridity-driven shift in biodiversity–soil multifunctionality relationships

Biodiversity-ecosystem functioning relationships may vary with climate. Here, the authors study relationships of plant and soil microbial diversity with soil nutrient multifunctionality in 130 dryland sites in China, finding a shift towards greater importance of soil microbial diversity in arid conditions.

Weigang Hu
Jinzhi Ran
Jianming Deng
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Development of miniature base editors using engineered IscB nickase

The miniature RNA-guided endonuclease IscB and its ωRNA were engineered for efficient gene editing in mammalian cells. Fusions of ‘enIscB’ to T5 exonuclease and cytosine or adenosine deaminase yield versatile tools for genome engineering.

Dingyi Han
Qingquan Xiao
Yingsi Zhou
Research25 May 2023
Nature Methods

Volume: 20, P: 1029-1036
Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation

The molecular mechanisms underlying Double-Null Prostate Cancer (DNPC) pathogenesis remain elusive. Here, the authors show that co-activation of HGF/MET and Wnt/β-catenin signaling in mouse prostates results in DNPC-like tumor lesions with elevated expression of XPO1 and ribosomal proteins.

Won Kyung Kim
Alyssa J. Buckley
Zijie Sun
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS

Single-cell, multiomic datasets are integrated using dimensionality reduction, imputation and batch correction.

Zhen He
Shuofeng Hu
Xiaomin Ying
ResearchOpen Access23 Jan 2024
Nature Biotechnology

Volume: 42, P: 1594-1605
Realization of quasicrystalline quadrupole topological insulators in electrical circuits

Higher order topological systems add an additional layer of complexity to the bulk boundary correspondence by being able to sustain additional modes such as corner and hinge states. Here, the authors use electrical circuits to realize a two-dimensional quasicrystalline quadrupole topological insulator without discrete translational symmetry and observe localized corner modes.

Bo Lv
Rui Chen
Dong-Hui Xu
ResearchOpen Access26 May 2021
Communications Physics

Volume: 4, P: 1-6
Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes

Activation of the androgen receptor (AR) through androgen binding is essential for prostate tumorigenesis. Here the authors show that AR activation in a subpopulation of prostatic progenitor cells can initiate prostatic intraepithelial neoplasia formation and promotes prostate cancer development through activation of IGF1 and Wnt/β-catenin signalling pathways.

Won Kyung Kim
Adam W. Olson
Zijie Sun
ResearchOpen Access28 Jul 2022
Nature Communications

Volume: 13, P: 1-18
Safety and efficacy of oral administrated cepharanthine in non-hospitalized, asymptomatic or mild COVID-19 patients: a Double-blind, randomized, placebo-controlled trial

Jianyi Wei
Shupeng Liu
Hai Li
ResearchOpen Access31 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Structural analysis of two human monoclonal antibodies that conform the antibody cocktail AZD7442, in complex with the RBD of SARS-CoV-2, reveal strong neutralization of SARS-CoV-2 variants of concern.

Jinhui Dong
Seth J. Zost
James E. Crowe Jr
Research21 Sept 2021
Nature Microbiology

Volume: 6, P: 1233-1244
Author Correction: Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

Anannya Bhattacharya
Lonzaric Jan
Antu K. Dey
Amendments and CorrectionsOpen Access18 Nov 2024
npj Vaccines

Volume: 9, P: 1
A comprehensive risk assessment method for hot work in underground mines based on G1-EWM and unascertained measure theory

Xiaoqiang Ding
Xiangliang Tian
Jinhui Wang
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Zhenqiang Su
Paweł P Łabaj
Leming Shi
Research24 Aug 2014
Nature Biotechnology

Volume: 32, P: 903-914
Author Correction: Realization of quasicrystalline quadrupole topological insulators in electrical circuits

Bo Lv
Rui Chen
Dong-Hui Xu
Amendments and CorrectionsOpen Access03 Jun 2021
Communications Physics

Volume: 4, P: 1
Wild rodents seed choice is relevant for sustainable agriculture

Yang Peng
Zhenbang Hu
Dawei Xin
ResearchOpen Access10 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
Exploring the relationship among Alzheimer’s disease, aging and cognitive scores through neuroimaging-based approach

Jinhui Sun
Jing-Dong J. Han
Weiyang Chen
ResearchOpen Access10 Nov 2024
Scientific Reports

Volume: 14, P: 1-16
Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

Anannya Bhattacharya
Lonzaric Jan
Antu K. Dey
ResearchOpen Access04 Apr 2024
npj Vaccines

Volume: 9, P: 1-14
Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma

Gehong Dong
Xuxiang Liu
Wing C. Chan
Research13 Jun 2022
Leukemia

Volume: 36, P: 2064-2075
The role of γ-aminobutyric acid in aluminum stress tolerance in a woody plant, Liriodendron chinense × tulipifera

Pengkai Wang
Yini Dong
Jinhui Chen
ResearchOpen Access01 Apr 2021
Horticulture Research

Volume: 8, P: 1-15

Search

Photoinduced formal [4 + 2] cycloaddition of two electron-deficient olefins and its application to the synthesis of lucidumone

Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma

Self-iterative multiple-instance learning enables the prediction of CD4⁺ T cell immunogenic epitopes

Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

The type III effector NopL interacts with GmREM1a and GmNFR5 to promote symbiosis in soybean

Nanoparticles for inducing Gaucher disease-like damage in cancer cells

Single-cell RNA sequencing reveals the effects of mental stress on mouse mammary tumors and the tumor microenvironment

Aridity-driven shift in biodiversity–soil multifunctionality relationships

Development of miniature base editors using engineered IscB nickase

Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation

Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS

Realization of quasicrystalline quadrupole topological insulators in electrical circuits

Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes

Safety and efficacy of oral administrated cepharanthine in non-hospitalized, asymptomatic or mild COVID-19 patients: a Double-blind, randomized, placebo-controlled trial

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Author Correction: Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

A comprehensive risk assessment method for hot work in underground mines based on G1-EWM and unascertained measure theory

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

Author Correction: Realization of quasicrystalline quadrupole topological insulators in electrical circuits

Wild rodents seed choice is relevant for sustainable agriculture

Exploring the relationship among Alzheimer’s disease, aging and cognitive scores through neuroimaging-based approach

Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma

The role of γ-aminobutyric acid in aluminum stress tolerance in a woody plant, Liriodendron chinense × tulipifera

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