Briefly, YAP 3′UTR is m5C modified under the promotion of NSUN2 and ALYREF, and this modification increases YAP mRNA stability and inhibits nearby m6A modification and miR-582-3p binding. Furthermore, YAP stimulates seven exosome biogenesis, transport and release-related genes including HRS, PLD2, RAB2B, RAB27A, RAB27B, VAMP and ATG7 in a Mycn- and SOX10-dependent manner.
- Wenjun Yu
- Congcong Zhang
- Jinjing Xia