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Nature Communications (5)
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Showing 1–10 of 10 results

Advanced filters: Author: Jinxue He Clear advanced filters

MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits

Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safety of gene editing.

Linyuan Ma
Jinxue Ruan
Jie Xu
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-11
EXPERT expands prime editing efficiency and range of large fragment edits

Prime editing systems (PEs) hold great promise though the editing range is limited to downstream sequences of the pegRNA nick. Here, the authors report the extended prime editor system (EXPERT), which overcomes this limitation enabling efficient editing on both sides of the pegRNA nick.

Youcai Xiong
Yinyu Su
Jinxue Ruan
ResearchOpen Access13 Feb 2025
Nature Communications

Volume: 16, P: 1-13
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.

Jinxue He
Zhong Zhang
Wen H. Shen
ResearchOpen Access05 Aug 2016
Nature Communications

Volume: 7, P: 1-13
USP7 V517F mutation as a mechanism of inhibitor resistance

Drug resistance is inevitable and pervasive. Here, the authors identify the V517F mutation as a significant contributor to USP7-mediated inhibitor resistance. This discovery offers valuable insights for the development of next-generation USP7 inhibitors.

Yu-Ling Miao
Fengying Fan
Jin-Xue He
ResearchOpen Access14 Mar 2025
Nature Communications

Volume: 16, P: 1-14
PTEN regulates DNA replication progression and stalled fork recovery

PTEN plays multiple roles in genome protection and tumour suppression. Here the authors show that PTEN depletion leads to impairment of replication progression, stalled fork recovery and diminished chromatin loading of Rad51, highlighting the interplay of PTEN with Rad51 in promoting stalled fork restart.

Jinxue He
Xi Kang
Wen H. Shen
Research09 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Synthesis of ursodeoxycholic acid by electrochemical stereoselective reduction of 7-ketolithocholic acid in aprotic solvents

Jinxue Shen
Dongdong Dong
Xuejun Cao
ResearchOpen Access11 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7

Wu Di
Xue Weinan
Li Mingqi
ResearchOpen Access04 Jul 2019
Cell Death & Disease

Volume: 10, P: 1-13
PTEN stabilizes TOP2A and regulates the DNA decatenation

Xi Kang
Chang Song
Yuxin Yin
ResearchOpen Access10 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer

Ning Zhang
Yu-Nan Tian
Jin-Xue He
ResearchOpen Access15 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-18
Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors

Zhong-min Yang
Xue-mei Liao
Ze-hong Miao
Research17 Apr 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1038-1047