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Showing 1–5 of 5 results

Advanced filters: Author: João Paulo Camporez Clear advanced filters

Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

Insulin stimulates TUG cleavage to translocate GLUT4 and enhance glucose uptake. Here Bogan and colleagues show that the TUG cleavage product regulates thermogenic gene transcription, thereby coupling glucose uptake to organismal energy expenditure.

Estifanos N. Habtemichael
Don T. Li
Jonathan S. Bogan
Research08 Mar 2021
Nature Metabolism

Volume: 3, P: 378-393
Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Anila K. Madiraju
Yang Qiu
Gerald I. Shulman
Amendments and Corrections07 Feb 2019
Nature Medicine

Volume: 25, P: 526-528
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Using ¹³C-labeled substrates in vivo, this group shows that metformin inhibits mG3PDH to reduce hepatic gluconeogenesis and lower glycemia by altering the redox potential of the cytosol of hepatocytes rather than affecting substrate availability.

Anila K. Madiraju
Yang Qiu
Gerald I. Shulman
Research23 Jul 2018
Nature Medicine

Volume: 24, P: 1384-1394
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

Targeting the adipokine adipsin and its downstream pathway may provide an approach for preservation of beta cell loss in type 2 diabetes.

Nicolás Gómez-Banoy
J. Sawalla Guseh
James C. Lo
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1739-1747
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ.

Alexander S. Banks
Fiona E. McAllister
Bruce M. Spiegelman
Research17 Nov 2014
Nature

Volume: 517, P: 391-395