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Showing 1–4 of 4 results
Advanced filters: Author: Joachim Baehring Clear advanced filters

  • High-grade meningiomas have a poor prognosis with virtually no effective systemic therapies. Here, the authors report results of a phase 2 clinical trial demonstrating safety and activity of pembrolizumab, a PD-1 inhibitor, in patients with recurrent and residual high-grade meningiomas.

    • Priscilla K. Brastianos
    • Albert E. Kim
    • Sandro Santagata
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-7

  • Primary CNS lymphoma, an extranodal non-Hodgkin's lymphoma that invades the nervous system, accounts for around 3% of all primary brain tumors. In this Review, Hochberg et al. highlight recent advances in our understanding of the pathogenesis of primary CNS lymphoma, and they discuss current approaches to the diagnosis and therapy of this condition.

    • Fred H Hochberg
    • Joachim M Baehring
    • Ephraim P Hochberg
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 24-35

  • Waldenstrom's macroglobulinemia—a condition that is characterized by overproduction of IgM antibodies and most commonly occurs in lymphoplasmacytic lymphoma—is often accompanied by nervous system complications, such as peripheral neuropathy or complications related to serum hyperviscosity. This Review provides an overview of the diagnosis and treatment of such neurological manifestations.

    • Joachim M Baehring
    • Ephraim P Hochberg
    • Fred H Hochberg
    Reviews
    Nature Clinical Practice Neurology
    Volume: 4, P: 547-556