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Showing 1–7 of 7 results
Advanced filters: Author: Joachim Forner Clear advanced filters

  • By editing the mitochondrial genome and screening a large number of deletion mutants, this study shows that clean knockout mutants for a mitochondrial gene can be obtained and used to construct a synthetic cytoplasmic male sterility system.

    • Joachim Forner
    • Dennis Kleinschmidt
    • Ralph Bock
    ResearchOpen Access
    Nature Plants
    Volume: 9, P: 1818-1831

  • Plastid genome engineering has been challenging in crops and model plants. Now, a method enables efficient plastid transformation by taking advantage of root-derived microcalli as source tissue and the knockout of a nuclear gene for efficient screening.

    • Stephanie Ruf
    • Joachim Forner
    • Ralph Bock
    Research
    Nature Plants
    Volume: 5, P: 282-289

  • Spatial control of auxin signaling maintains a balance between stem-cell self-renewal and differentiation at the plant shoot apex. Here Ma et al. show that rheostatic control of auxin response by the WUSCHEL transcription factor maintains stem cells by conferring resistance to auxin mediated differentiation.

    • Yanfei Ma
    • Andrej Miotk
    • Jan U. Lohmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • A method for targeted mutagenesis of mitochondrial genomes is presented. It combines site-specific DNA cleavage with selection for mutations that confer cleavage resistance, and produces genetically stable plants with edited mitochondrial genomes.

    • Joachim Forner
    • Dennis Kleinschmidt
    • Ralph Bock
    ResearchOpen Access
    Nature Plants
    Volume: 8, P: 245-256

  • Antimicrobial peptides (AMPs) are promising next-generation antibiotics, but are difficult to produce due to the toxicity to bacterial hosts. Here, the authors report the utilization of transplastomic tobacco plants for AMPs production without cytotoxic effects via inducible expression systems and fusions to cleavable carrier protein.

    • Matthijs P. Hoelscher
    • Joachim Forner
    • Ralph Bock
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Cholangiocarcinoma (CCA) comprises heterogeneous biliary malignant tumours, and their incidence is increasing worldwide. This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research.

    • Jesus M. Banales
    • Jose J. G. Marin
    • Gregory J. Gores
    ReviewsOpen Access
    Nature Reviews Gastroenterology & Hepatology
    Volume: 17, P: 557-588