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A guide to uraemic toxicity

This Review provides a guide to metabolite retention in kidney disease and includes an overview of key uraemic toxins and the complex mechanisms underlying their toxicity, as well as a discussion of key strategies with the potential to prevent or mitigate their adverse effects.

Griet Glorieux
Stéphane Burtey
Raymond Vanholder
Reviews23 Sept 2025
Nature Reviews Nephrology

P: 1-19
Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research13 Feb 2023
Nature Immunology

Volume: 24, P: 412-413
Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor

Vera Jankowski
Markus Tölle
Joachim Jankowski
Research23 Jan 2005
Nature Medicine

Volume: 11, P: 223-227
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Overabundance of apolipoprotein C3 (ApoC3) is associated with atherosclerosis. Speer and colleagues demonstrate that ApoC3 activates the NLRP3 inflammasome via a non-canonical pathway contributing to inflammation and development of atherosclerosis.

Stephen Zewinger
Jochen Reiser
Thimoteus Speer
Research09 Dec 2019
Nature Immunology

Volume: 21, P: 30-41
An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances

Tino Vollmer
Börje Ljungberg
Bernd G. Stegmayr
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
Post-translational modifications in kidney diseases and associated cardiovascular risk

Chronic kidney disease (CKD) is associated with several alterations in protein post-translational modifications. Here, the authors examine the evidence of these alterations, their links with CKD progression and cardiovascular risk in patients with CKD, and their potential clinical applications.

Heidi Noels
Vera Jankowski
Joachim Jankowski
Reviews25 Apr 2024
Nature Reviews Nephrology

Volume: 20, P: 495-512
Alterations of the peptidomic composition of peripheral plasma after portal hypertension correction by transjugular intrahepatic portosystemic shunt

Giulia Ilaria Bagarolo
Shruti Bhargava
Joachim Jankowski
ResearchOpen Access10 Jun 2024
npj Gut and Liver

Volume: 1, P: 1-12
Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery

Heidi Noels
Wendy Theelen
Christian Stoppe
ResearchOpen Access07 Aug 2018
Scientific Reports

Volume: 8, P: 1-12
Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations

Chronic kidney disease (CKD) is associated with alterations in serum lipid profiles that contribute to kidney and cardiovascular disease. Here, the authors examine these changes in serum levels, metabolism and post-translational modifications of lipoproteins and fatty acids that characterize CKD-associated dyslipidaemia.

Heidi Noels
Michael Lehrke
Joachim Jankowski
Reviews10 May 2021
Nature Reviews Nephrology

Volume: 17, P: 528-542
Xanthohumol exerts anti-inflammatory effects in an in vitro model of mechanically stimulated cementoblasts

Christian Niederau
Shruti Bhargava
Michael Wolf
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Urine peptidome analysis in cardiorenal syndrome reflects molecular processes

Eleni Petra
Tianlin He
Joachim Jankowski
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-11
Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe^−/− mice

Sai Sahana Sundararaman
Linsey J. F. Peters
Emiel P. C. van der Vorst
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-9
Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro

Björn Hegner
Theres Schaub
Duska Dragun
ResearchOpen Access14 Aug 2018
Scientific Reports

Volume: 8, P: 1-11
Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients

Ophélie Fourdinier
Eva Schepers
Andrej Wiecek
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis

Magdalena Krochmal
Katryna Cisek
Joachim Jankowski
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-13

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A guide to uraemic toxicity

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances

Post-translational modifications in kidney diseases and associated cardiovascular risk

Alterations of the peptidomic composition of peripheral plasma after portal hypertension correction by transjugular intrahepatic portosystemic shunt

Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery

Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations

Xanthohumol exerts anti-inflammatory effects in an in vitro model of mechanically stimulated cementoblasts

Urine peptidome analysis in cardiorenal syndrome reflects molecular processes

Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe^−/− mice

Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro

Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis

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