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Showing 1–2 of 2 results
Advanced filters: Author: Joan Font-Burgada Clear advanced filters
  • dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here the authors report that dDsk2 regulates RNA polymerase II pausing by preventing H2Bub1 deubiquitylation, suggesting a nonproteolytic function of dDsk2.

    • Roman Kessler
    • Johan Tisserand
    • Fernando Azorín
    Research
    Nature Communications
    Volume: 6, P: 1-14
  • IgA plasmocytes are shown to promote resistance to the immunogenic chemotherapeutic oxaliplatin in prostate cancer mouse models by inhibiting activation of cytotoxic T cells; immunosuppressive plasma cells, which are also found in human-therapy-resistant prostate cancer, are generated in response to TGFβ, and their functionality depends on PD-L1 expression and IL-10 secretion.

    • Shabnam Shalapour
    • Joan Font-Burgada
    • Michael Karin
    Research
    Nature
    Volume: 521, P: 94-98