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Cell Death and Differentiation (2)
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Showing 1–5 of 5 results

Advanced filters: Author: Joanna Maria Merchut-Maya Clear advanced filters

NAD⁺ regulates nucleotide metabolism and genomic DNA replication

Munk et al. show that exogenous NAD⁺, but not its precursors, induces metabolic changes in mitochondria affecting nucleotide metabolism with impacts on genomic DNA synthesis and genome integrity.

Sebastian Howen Nesgaard Munk
Joanna Maria Merchut-Maya
Apolinar Maya-Mendoza
ResearchOpen Access13 Nov 2023
Nature Cell Biology

Volume: 25, P: 1774-1786
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

AMBRA1-mediated degradation of cyclin D through CRL4–DDB1 regulates cell proliferation and prevents replication stress in neurodevelopment and cancer.

Emiliano Maiani
Giacomo Milletti
Francesco Cecconi
Research14 Apr 2021
Nature

Volume: 592, P: 799-803
High speed of fork progression induces DNA replication stress and genomic instability

Inhibition of PARP is shown to accelerate the speed of replication fork elongation, which prevents fork stalling and induces DNA damage, with implications for genomic instability and cancer treatment.

Apolinar Maya-Mendoza
Pavel Moudry
Jiri Bartek
Research27 Jun 2018
Nature

Volume: 559, P: 279-284
Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability

Joanna Maria Merchut-Maya
Jiri Bartek Jr
Jiri Bartek
Research22 Feb 2022
Cell Death & Differentiation

Volume: 29, P: 1639-1653
Autophagy role(s) in response to oncogenes and DNA replication stress

Riccardo Vanzo
Jirina Bartkova
Jiri Bartek
ResearchOpen Access14 Aug 2019
Cell Death & Differentiation

Volume: 27, P: 1134-1153