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Showing 1–9 of 9 results
Advanced filters: Author: Jocelyn Charlton Clear advanced filters

  • A lag in nascent strand DNA methylation contributes to heterogeneous methylation in asynchronous cell populations, but cancer cells and active transcription factor binding sites preserve heterogeneity even after cell cycle arrest.

    • Jocelyn Charlton
    • Timothy L. Downing
    • Alexander Meissner
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 327-332

  • Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity.

    • Christina Galonska
    • Jocelyn Charlton
    • Alexander Meissner
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Hoetker et al. show that H3K36 methylation exerts a dual role in cell identity maintenance: it integrates TGFβ signals at mesenchymal targets to keep them active and prevents the activation of alternative lineage programmes via enhancer methylation.

    • Michael S. Hoetker
    • Masaki Yagi
    • Konrad Hochedlinger
    Research
    Nature Cell Biology
    Volume: 25, P: 1121-1134

  • ALS and FTLD are both characterized by insoluble cytoplasmic depositions of TDP43. Here the authors show that the nucleopore protein NUP62 is mislocalized in C9orf72 and sporadic ALS/FTLD and propose that it interacts with TDP-43 to promote its insolubility.

    • Amanda M. Gleixner
    • Brandie Morris Verdone
    • Christopher J. Donnelly
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Investigation of FOXA2, GATA4 and OCT4 binding across several cell types provides insights into the genetic determinants and epigenetic effects of pioneer-factor occupancy. The data suggest that FOXA2 samples most of its potential binding sites but is stabilized at only a subset of targets.

    • Julie Donaghey
    • Sudhir Thakurela
    • Alexander Meissner
    Research
    Nature Genetics
    Volume: 50, P: 250-258