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Showing 1–9 of 9 results
Advanced filters: Author: Joel N. Blankson Clear advanced filters

  • As the SARS-SoV-2 pandemic progressed and the vaccinated population increased, a number of variants of concerns that circumvented the vaccine induced immunity emerged. Here the authors compare SARS-SoV-2 mRNA vaccine responses in pregnant women and other people, characterising the antibody response and Fc functions, and potency against a range of variants of concern.

    • Andrew P. Hederman
    • Harini Natarajan
    • Margaret E. Ackerman
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Certain human leukocyte antigen (HLA) alleles are associated with vigorous human immunodeficiency virus (HIV)-specific CD8+ T cell responses and good clinical outcomes. A new study suggests that CD8+ T cell–mediated killing of regulatory CD4+ T cells may partially explain how people with these protective alleles control HIV-1 replication (pages 989–995).

    • Joel N Blankson
    News & Views
    Nature Medicine
    Volume: 17, P: 927-928

  • Detection of persistent replication-competent HIV in monocytes from virologically suppressed people with HIV indicates that monocytes have a role as a latent reservoir.

    • Rebecca T. Veenhuis
    • Celina M. Abreu
    • Janice E. Clements
    ResearchOpen Access
    Nature Microbiology
    Volume: 8, P: 833-844

  • Substitutions in CD8+ T cell epitopes in viral proteins can alter the complex interaction between viruses and host immunity. Reduced viral fitness and recognition of altered and subdominant epitopes are possible outcomes.

    • Joel N Blankson
    • Justin R Bailey
    • Robert F Siliciano
    News & Views
    Nature Immunology
    Volume: 7, P: 121-122

  • An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

    • Katherine M. Bruner
    • Zheng Wang
    • Robert F. Siliciano
    Research
    Nature
    Volume: 566, P: 120-125

  • Recent efforts have focused on the development of therapies that could eradicate HIV-1 infection or achieve a durable remission of viraemia in the absence of antiretroviral therapy; however, targeting viral quiescence within specific cellular reservoirs so that residual infection can be cleared remains a challenge. In this Review, Margolis and colleagues explore new approaches to eradicate established HIV-1 infection.

    • Nancie M. Archin
    • Julia Marsh Sung
    • David M. Margolis
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 750-764