In a mouse model for skin cancer, β-catenin signalling is shown to be important to specifically maintain a population of cancer stem cells. These cancer stem cells share properties with normal bulge stem cells and may therefore be derived from those cell. As β -catenin signalling isn't required for normal skin homeostasis, it may be a suitable new target for skin cancer therapy.
- Ilaria Malanchi
- Hector Peinado
- Joerg Huelsken
