Nature Search

Unbroken \({{{\mathscr{P}}}}{{{\mathscr{T}}}}\)-symmetry in the absence of gain or loss

The conventional implementation of parity-time symmetry relies on the interplay of gain and loss. Here, Bentzien et al. present a novel approach towards non-Hermiticity that leverages nonorthogonal modes in coupled waveguides explicitly avoiding the use of either gain or loss.

Johannes Bentzien
Julien Pinske
Alexander Szameit
ResearchOpen Access05 Sept 2025
Nature Communications

Volume: 16, P: 1-8
Smooth trends in fermium charge radii and the impact of shell effects

Laser spectroscopy measurements of the fermium isotopic chain show a smooth trend in the nuclear size of heavy actinide elements, and diminishing shell effects on the size evolution compared with lighter nuclei.

Jessica Warbinek
Elisabeth Rickert
Klaus Wendt
ResearchOpen Access30 Oct 2024
Nature

Volume: 634, P: 1075-1079
Performance on innate behaviour during early development as a function of stress level

Soojin Ryu
Rodrigo J. De Marco
ResearchOpen Access10 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

The regulation of tumor inflammation is incompletely understood and the role of B cells is unclear. Here, the authors show that a specific subtype of B cells is induced in melanoma and required to recruit T lymphocytes and elicit inflammation.

Johannes Griss
Wolfgang Bauer
Stephan N. Wagner
ResearchOpen Access13 Sept 2019
Nature Communications

Volume: 10, P: 1-14
A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection

A human antithrombin glycosylation isoform dampens inflammatory responses and protects mice against lethal bacterial infection.

Praveen Papareddy
Madlen Rossnagel
Heiko Herwald
Research23 Sept 2019
Nature Microbiology

Volume: 4, P: 2442-2455
Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour

Behavioural adaptations in response to stress are thought to be regulated by rapid neurotransmitter action, followed by slower hormonal signalling. Here, using optogenetic approaches, the authors find corticotroph cell populations are capable of rapidly modulating avoidance behaviours immediately after the onset of stress.

Rodrigo J. De Marco
Theresa Thiemann
Soojin Ryu
ResearchOpen Access20 Sept 2016
Nature Communications

Volume: 7, P: 1-11
Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Axel Schmidt
Magdalena Danyel
Matias Wagner
Amendments and CorrectionsOpen Access24 Jun 2025
Nature Genetics

Volume: 57, P: 1790-1791
Oestrogens regulate divergent effects of prolactin in the ovary

Johannes D. Veldhuis
James M. Hammond
Research20 Mar 1980
Nature

Volume: 284, P: 262-264
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Exome sequencing within a structured diagnostic process for rare diseases in Germany shows how facial image analysis and machine learning can guide variant prioritization and uncover many ultrarare diseases.

Axel Schmidt
Magdalena Danyel
Matias Wagner
ResearchOpen Access22 Jul 2024
Nature Genetics

Volume: 56, P: 1644-1653
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

The authors developed small-molecule inhibitors of STOML3 oligomerization, a membrane protein that interacts with mechanosensitive ion channels, such as Piezo2. One of these molecules was effective in silencing touch receptors and reversed touch-evoked pain associated with nerve injury or diabetic neuropathy.

Christiane Wetzel
Simone Pifferi
Gary R Lewin
Research12 Dec 2016
Nature Neuroscience

Volume: 20, P: 209-218
PTEN mutations in gliomas and glioneuronal tumors

Eva-Maria Duerr
Britta Rollbrocker
Andreas von Deimling
Research15 May 1998
Oncogene

Volume: 16, P: 2259-2264
Examining the role of personality functioning in a hierarchical taxonomy of psychopathology using two years of ambulatory assessed data

André Kerber
Johannes C. Ehrenthal
Christine Knaevelsrud
ResearchOpen Access24 Aug 2024
Translational Psychiatry

Volume: 14, P: 1-13
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Thomas Vogl
Klaus Tenbrock
Johannes Roth
Research02 Sept 2007
Nature Medicine

Volume: 13, P: 1042-1049
Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription

Three-dimensional genome organization is important for transcription regulation. Here the authors show that microRNA 9 mediates the formation of G-quadruplexes and the looping of promoters and super-enhancers in genes activated by transforming growth factor beta 1signaling.

Julio Cordero
Guruprasadh Swaminathan
Guillermo Barreto
ResearchOpen Access20 Dec 2024
Nature Communications

Volume: 15, P: 1-21
TGFβR signalling controls CD103⁺CD11b⁺ dendritic cell development in the intestine

Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103⁺CD11b⁺ intestinal DCs from CD103⁻CD11b⁺ cells and that they contribute to the generation of Th17 and regulatory T cells

C. C. Bain
J. Montgomery
A. McI. Mowat
ResearchOpen Access20 Sept 2017
Nature Communications

Volume: 8, P: 1-12
The landscape of genomic alterations across childhood cancers

Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

Susanne N. Gröbner
Barbara C. Worst
Stefan M. Pfister
ResearchOpen Access28 Feb 2018
Nature

Volume: 555, P: 321-327
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-mediated DNA demethylation and transcription.

Stephanie Dobersch
Karla Rubio
Guillermo Barreto
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-20
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.

Lena M. Kranz
Mustafa Diken
Ugur Sahin
Research01 Jun 2016
Nature

Volume: 534, P: 396-401
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

Stefanie Lesch
Viktoria Blumenberg
Sebastian Kobold
Research03 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 1246-1260
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17
Author Correction: The landscape of genomic alterations across childhood cancers

Susanne N. Gröbner
Barbara C. Worst
Stephanie Sungalee
Amendments and Corrections06 Jun 2018
Nature

Volume: 559, P: E10
Amount of ascites impacts survival in patients with hepatocellular carcinoma undergoing transarterial chemoembolization advocating for volumetric assessment

Lukas Müller
Daniel Bender
Felix Hahn
ResearchOpen Access17 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

The authors describe the MiCEE complex, which comprises Mirlet7d ncRNA duplexes bound by C1D, the RNA exosome complex, and PRC2. MiCEE regulates bidirectionally transcribed loci and nucleolar organization.

Indrabahadur Singh
Adriana Contreras
Guillermo Barreto
Research04 Jun 2018
Nature Genetics

Volume: 50, P: 990-1001
Molecular dissection of human Argonaute proteins by DNA shuffling

What makes human Argonaute 2 (Ago2) slicing competent in contrast to AGO1, 3 and 4, which lack RNA cleavage activity, has remained unclear. Now, a molecular evolution approach, called DNA family shuffle (DFS), reveals features of AGO1, 3 and 4 that explain their RNA-slicing deficiency and suggests the juxtaposition and combined action of multiple disseminated protein modules.

Nina Schürmann
Leonardo G Trabuco
Dirk Grimm
Research09 Jun 2013
Nature Structural & Molecular Biology

Volume: 20, P: 818-826
Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

The study performed on a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.

Willem B. Bruin
Paul Zhutovsky
Moji Aghajani
Research10 Jan 2024
Nature Mental Health

Volume: 2, P: 104-118
Generation of Human Pulmonary Microvascular Endothelial Cell Lines

Vera Krump-Konvalinkova
Fernando Bittinger
C James Kirkpatrick
Research01 Dec 2001
Laboratory Investigation

Volume: 81, P: 1717-1727
Tunable long-distance spin transport in a crystalline antiferromagnetic iron oxide

Tunable spin transport over long distances is demonstrated through the antiferromagnetic insulator haematite, paving the way to the development of spin-logic devices based on antiferromagnetic insulators.

R. Lebrun
A. Ross
M. Kläui
Research12 Sept 2018
Nature

Volume: 561, P: 222-225
Seep-carbonate lamination controlled by cyclic particle flux

Tobias Himmler
Germain Bayon
Gerhard Bohrmann
ResearchOpen Access23 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
Cortisol reactivity in patients with anorexia nervosa after stress induction

Ileana Schmalbach
Benedict Herhaus
Katja Petrowski
ResearchOpen Access10 Aug 2020
Translational Psychiatry

Volume: 10, P: 1-15
Donor CD4 T cells convert mixed to full donor T-cell chimerism and replenish the CD52-positive T-cell pool after alemtuzumab-based T-cell-depleted allo-transplantation

R G Meyer
E M Wagner
W Herr
Research17 Aug 2009
Bone Marrow Transplantation

Volume: 45, P: 668-674
Individualizing deep dynamic models for psychological resilience data

Göran Köber
Shakoor Pooseh
Harald Binder
ResearchOpen Access16 May 2022
Scientific Reports

Volume: 12, P: 1-10
Magnetic super-structure and active surface role in the onset of magnetic excitons revealed in TbCu₂ nanoparticles

Antiferromagnetic materials are receiving renewed interest for their potential use in spintronics and information technology. Here, neutron scattering experiments reveal that TbCu₂, a collinear antiferromagnet, can host spiral-like magnetic superstructures both in bulk form and small nanoparticle ensembles.

Elizabeth M. Jefremovas
María de la Fuente Rodríguez
Luis Fernández Barquín
ResearchOpen Access04 Aug 2023
Communications Materials

Volume: 4, P: 1-8
Defining habitat covariates in camera-trap based occupancy studies

Jürgen Niedballa
Rahel Sollmann
Andreas Wilting
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Anisotropies and magnetic phase transitions in insulating antiferromagnets determined by a Spin-Hall magnetoresistance probe

Antiferromagnets are expected to be a key part of next generation electronic devices however their magnetic interactions prove difficult to access. Here, the authors demonstrate that the surface sensitive spin-Hall magnetoresistance, along with a simple analytical model, can successfully probe the internal anisotropies of the model antiferromagnet hematite (α-Fe₂O₃).

R. Lebrun
A. Ross
M. Kläui
ResearchOpen Access16 May 2019
Communications Physics

Volume: 2, P: 1-7
Harmonised statistics and maps of forest biomass and increment in Europe

Valerio Avitabile
Roberto Pilli
Sarah Mubareka
ResearchOpen Access06 Mar 2024
Scientific Data

Volume: 11, P: 1-17

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