Caspases, and the proximal regulators of caspases, are central to the core machinery of apoptosis. The results of a genome-wide silencing screen in Drosophila—using a strategy combining a library of double-stranded RNAs together with a chemical antagonist of Inhibitor of apoptosis proteins (IAPs)—now reveals a set of validated targets necessary for cell death provoked by several stimuli, as well as a new effector for apoptosis, Tango7.
- Su Kit Chew
- Po Chen
- John M. Abrams
