Nature Search

Machine-guided design of cell-type-targeting cis-regulatory elements

A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.

Sager J. Gosai
Rodrigo I. Castro
Ryan Tewhey
ResearchOpen Access23 Oct 2024
Nature

Volume: 634, P: 1211-1220
Annual-scale variability in both the rotation rate and near surface of Earth’s inner core

Earth’s inner core has both changed its relative rotation rate and deformed in the past few decades, according to an analysis of seismic waves recorded when the inner core occupied the same relative location owing to its changing rotation rate.

John E. Vidale
Wei Wang
Keith Koper
Research10 Feb 2025
Nature Geoscience

Volume: 18, P: 267-272
Deep Machine Learning Techniques for the Detection and Classification of Sperm Whale Bioacoustics

Peter C. Bermant
Michael M. Bronstein
David F. Gruber
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
An estimate of the impact rate on Mars from statistics of very-high-frequency marsquakes

A subset of seismic events recorded by InSight’s seismometer attributed to impacts was used to derive a new estimate of the current impact rate on Mars. The results suggest a rate higher than predicted by orbital imaging, but consistent with theoretical rates.

Géraldine Zenhäusern
Natalia Wójcicka
Domenico Giardini
ResearchOpen Access28 Jun 2024
Nature Astronomy

Volume: 8, P: 1138-1147
Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis

With increasing river flow, sand dunes on the riverbed initially grow and eventually flatten out. However, flume experiments show that dune height distributions under high flow are bimodal, suggesting flickering between high and low dune heights.

Damien Restagno
Mayank Saraswat
Jamey D. Marth
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-13
The depth dependence of earthquake duration and implications for rupture mechanisms

John E. Vidale
Heidi Houston
Research02 Sept 1993
Nature

Volume: 365, P: 45-47
Inner core backtracking by seismic waveform change reversals

Matching seismic waveforms show that the inner core of Earth gradually super-rotated from 2003 to 2008, and then more slowly sub-rotated from 2008 to 2023 back through the same path.

Wei Wang
John E. Vidale
Ruoyan Wang
ResearchOpen Access12 Jun 2024
Nature

Volume: 631, P: 340-343
Slow differential rotation of the Earth's inner core indicated by temporal changes in scattering

John E. Vidale
Doug A. Dodge
Paul S. Earle
Research25 May 2000
Nature

Volume: 405, P: 445-448
An initial map of fine-scale heterogeneity in the Earth’s inner core

Two regions of fine-scale heterogeneity in Earth’s inner core may be due to the random alignment of fast-freezing crystals associated with downwelling in the mantle and outer core, according to a 3D map of inner-core seismic data.

Wei Wang
John E. Vidale
Research24 Feb 2022
Nature Geoscience

Volume: 15, P: 240-244
Fine-scale heterogeneity in the Earth's inner core

John E. Vidale
Paul S. Earle
Research16 Mar 2000
Nature

Volume: 404, P: 273-275
Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Low total energy expenditure (TEE) has been a hypothesized risk factor for weight gain, but longitudinal repeatability of TEE is incompletely understood. Here the authors report that TEE is repeatable for adults, but not for children, and increases in TEE (adjusted for fat-free mass, fat mass, age and sex) are not associated with body composition changes in short-term longitudinal analyses.

Rebecca Rimbach
Yosuke Yamada
John R. Speakman
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-8
Co-occurrence networks reveal more complexity than community composition in resistance and resilience of microbial communities

Fungi are expected to be more resistant and less resilient than bacteria to environmental disturbances. Here, the authors report complex responses by microbial co-occurrence networks to drought in an agricultural system, challenging simple predictions of fungal and bacterial drought responses.

Cheng Gao
Ling Xu
John W. Taylor
ResearchOpen Access05 Jul 2022
Nature Communications

Volume: 13, P: 1-12
Dynamics of seismogenic volcanic extrusion at Mount St Helens in 2004–05

Richard M. Iverson
Daniel Dzurisin
James W. Vallance
Research23 Nov 2006
Nature

Volume: 444, P: 439-443
Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

Lois M. Mulligan
Charis Eng
Bruce A.J. Ponder
Research01 Jan 1994
Nature Genetics

Volume: 6, P: 70-74
Variations in earthquake rupture properties along the Gofar transform fault, East Pacific Rise

Mid-ocean ridge transform faults experience more foreshocks than continental faults, yet the mainshock rarely ruptures the entire fault. Analysis of seismic data from the Gofar transform fault at the East Pacific Rise indicates that the foreshock region has different material properties from the mainshock region, and acts as a barrier to rupture propagation.

Jeffrey J. McGuire
John A. Collins
Robert D. van der Hilst
Research22 Apr 2012
Nature Geoscience

Volume: 5, P: 336-341
Drift-dependent changes in iceberg size-frequency distributions

James D. Kirkham
Nick J. Rosser
Witold Szczuciński
ResearchOpen Access22 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Underlying dimensions of real-time word recognition in cochlear implant users

People recognize a word by resolving competition between similar sounding words as it unfolds over time. Here, the authors use the visual world paradigm in cochlear implant users to characterize the dimensionality of individual differences in how people resolve such lexical competition.

Bob McMurray
Francis X. Smith
Sarah Colby
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-19
Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation

Robbins and colleagues show that cigarette smoke-induced endothelial dysfunction enables atherosclerotic plaque macrophages to drive abdominal aortic aneurysm formation in a mouse model of atherosclerosis.

Danya Thayaparan
Takuo Emoto
Clinton S. Robbins
Research22 Apr 2025
Nature Immunology

Volume: 26, P: 706-721
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs
Adam V. Patterson
Adrian L. Harris
Research01 May 1997
Nature Medicine

Volume: 3, P: 515-520
Neonatal antipredator tactics shape female movement patterns in large herbivores

Combining a large-scale dataset of 23 ungulate species (in which newborns follow contrasting tactics of predator avoidance) with continuous-time stochastic movement models, the authors reveal that there are multiple dimensions of maternal movement behaviour and space use.

Kamal Atmeh
Christophe Bonenfant
Anne Loison
Research04 Dec 2024
Nature Ecology & Evolution

Volume: 9, P: 142-152
Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy

There is a genetic component to the risk of severe COVID-19, but the genetic effects are difficult to separate from social constructs that covary with genetic ancestry. To address this, the authors identify determinants of COVID-19 severity using admixture mapping, viral phylodynamics, and host immune and metagenomic sequencing.

Victoria N. Parikh
Alexander G. Ioannidis
Euan A. Ashley
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-10
Upper-mantle seismic discontinuities and the thermal structure of subduction zones

John E. Vidale
Harley M. Benz
Research23 Apr 1992
Nature

Volume: 356, P: 678-683
Inhibiting Ca²⁺ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia

Early in Alzheimer’s disease (AD), brain blood flow is reduced by pericytes constricting capillaries. Korte et al. show that oral nimodipine can reverse this and decrease brain hypoxia. Blocking capillary constriction is a potential add-on therapy in AD.

Nils Korte
Anna Barkaway
David Attwell
ResearchOpen Access18 Sept 2024
Nature Neuroscience

Volume: 27, P: 2086-2100
Emergence of methicillin resistance predates the clinical use of antibiotics

Methicillin-resistant strains of Staphylococcus aureus appeared in European hedgehogs in the pre-antibiotic era as a co-evolutionary adaptation to antibiotic-producing dermatophytes and have spread within the local hedgehog populations and between hedgehogs and secondary hosts.

Jesper Larsen
Claire L. Raisen
Anders R. Larsen
ResearchOpen Access05 Jan 2022
Nature

Volume: 602, P: 135-141
Leopard seal song patterns have similar predictability to nursery rhymes

Lucinda E. H. Chambers
John R. Buck
Tracey L. Rogers
ResearchOpen Access31 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects of ATG in mouse models of DKD.

Yifei Zhong
Kyung Lee
Ruijie Liu
ResearchOpen Access04 Oct 2019
Nature Communications

Volume: 10, P: 1-15
The evolution of reproductive modes and life cycles in amphibians

Here, the authors use reproductive mode data with matching phylogenetic data to explore the evolution of reproductive mode, transitions between reproductive modes, and diversification rates in amphibians.

H. Christoph Liedtke
John J. Wiens
Ivan Gomez-Mestre
ResearchOpen Access17 Nov 2022
Nature Communications

Volume: 13, P: 1-15
A sharp and flat section of the core–mantle boundary

John E. Vidale
Harley M. Benz
Research15 Oct 1992
Nature

Volume: 359, P: 627-629
A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

Metastatic clear cell renal cell carcinoma has a poor prognosis. Here, the authors use single cell RNA-seq to show a distinct gene expression signature in the primary tumour of metastatic patients, and highlights immune cell receptor interactions as potential therapeutic targets.

Adele M. Alchahin
Shenglin Mei
Ninib Baryawno
ResearchOpen Access30 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Continental-scale decrease in net primary productivity in streams due to climate warming

An increase in stream temperature leads to a convergence of metabolic balance, overall decline in net ecosystem productivity, and higher CO₂ emissions from streams, according to analyses of temperature sensitivity of stream metabolism across six biomes.

Chao Song
Walter K. Dodds
Ford Ballantyne IV
Research21 May 2018
Nature Geoscience

Volume: 11, P: 415-420
Non-volcanic tremor driven by large transient shear stresses

Justin L. Rubinstein
John E. Vidale
Stephen D. Malone
Research02 Aug 2007
Nature

Volume: 448, P: 579-582
Mantle compensation of active metamorphic core complexes at Woodlark rift in Papua New Guinea

Geoffrey A. Abers
Aaron Ferris
Brian Taylor
Research22 Aug 2002
Nature

Volume: 418, P: 862-865
Ten years of biotech gaffes

Much of biotech's success has been built on lessons learned from mistakes. But the past ten years has also witnessed mistakes many in biotech would prefer to forget.

John Hodgson
Comments & Opinion08 Mar 2006
Nature Biotechnology

Volume: 24, P: 270-273
Quasi-extinction risk and population targets for the Eastern, migratory population of monarch butterflies (Danaus plexippus)

Brice X. Semmens
Darius J. Semmens
Orley R. Taylor
ResearchOpen Access21 Mar 2016
Scientific Reports

Volume: 6, P: 1-7
Grandiose narcissism, unfounded beliefs, and behavioral reactions during the COVID-19 pandemic

Magdalena Żemojtel-Piotrowska
Artur Sawicki
Somayeh Zand
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
Calls for a ceasefire in the science wars

John Henry
Books & Arts08 Oct 1998
Nature

Volume: 395, P: 557-558
Versatile clinical movement analysis using statistical parametric mapping in MovementRx

Amr Alhossary
Todd Pataky
Cyril John Donnelly
ResearchOpen Access10 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
DNA synthesis and biological security

A group of academics, industry executives and security experts propose an oversight framework to address concerns over the security of research involving commercial DNA synthesis.

Hans Bügl
John P Danner
Drew Endy
Comments & Opinion01 Jun 2007
Nature Biotechnology

Volume: 25, P: 627-629
Spatial omics and multiplexed imaging to explore cancer biology

This Review describes spatial omics and multiplexed imaging technologies and their current and future impact in studying tumor heterogeneity and cancer biology.

Sabrina M. Lewis
Marie-Liesse Asselin-Labat
Shalin H. Naik
Reviews02 Aug 2021
Nature Methods

Volume: 18, P: 997-1012
Homeostasis of αβ TCR⁺ T cells

Philippa Marrack
Jeremy Bender
John Kappler
Reviews01 Aug 2000
Nature Immunology

Volume: 1, P: 107-111
Long term structural and functional neural changes following a single infusion of Ketamine in PTSD

Or Duek
Nachshon Korem
Ilan Harpaz-Rotem
ResearchOpen Access03 Jun 2023
Neuropsychopharmacology

Volume: 48, P: 1648-1658
Bayesian inference of chemical exposures from NHANES urine biomonitoring data

Zachary Stanfield
R. Woodrow Setzer
John F. Wambaugh
Research17 Aug 2022
Journal of Exposure Science & Environmental Epidemiology

Volume: 32, P: 833-846
High flux novel polymeric membrane for renal applications

Christa N. Hestekin
Efecan Pakkaner
Ira Kurtz
ResearchOpen Access20 Jul 2023
Scientific Reports

Volume: 13, P: 1-11
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
Modelling menstrual cycle length in athletes using state-space models

Thiago de Paula Oliveira
Georgie Bruinvels
John Newell
ResearchOpen Access20 Aug 2021
Scientific Reports

Volume: 11, P: 1-14
African forest elephant movements depend on time scale and individual behavior

Christopher Beirne
Thomas M. Houslay
John R. Poulsen
ResearchOpen Access16 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Ceramide-orchestrated signalling in cancer cells

Ceramide induces apoptosis, autophagy and cell cycle arrest and it is therefore often metabolized in tumour cells to suppress its function and promote proliferation. As also discussed in this Review, there are efforts to increase ceramide levels as a therapeutic avenue.

Samy A. F. Morad
Myles C. Cabot
Reviews13 Dec 2012
Nature Reviews Cancer

Volume: 13, P: 51-65
Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury

Danielle E. Soranno
Peter Baker II
Sarah Faubel
ResearchOpen Access12 Jan 2022
Scientific Reports

Volume: 12, P: 1-12

Search

Filter By:

Search

Quick links