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Showing 1–6 of 6 results
Advanced filters: Author: John Fielden Clear advanced filters

  • Inhibitors of the protein kinase Wee1 are promising drugs for cancer therapy. Here, the authors show that these drugs activate the integrated stress response via GCN2, synergising with mRNA translation defects. They suggest strategies such as PROTACs or ISR inhibitors to improve WEE1 mediated toxicity.

    • Jordan C. J. Wilson
    • JiaYi Zhu
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.

    • John Fielden
    • Sebastian M. Siegner
    • Jacob E. Corn
    ResearchOpen Access
    Nature
    Volume: 640, P: 1093-1102

  • Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.

    • John Fielden
    • Katherine Wiseman
    • Kristijan Ramadan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.

    • Swagata Halder
    • Ignacio Torrecilla
    • Kristijan Ramadan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

    • Leming Shi
    • Gregory Campbell
    • Russell D Wolfinger
    Research
    Nature Biotechnology
    Volume: 28, P: 827-838