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Showing 1–5 of 5 results
Advanced filters: Author: John J Sakon Clear advanced filters

  • While the contribution of sharp wave ripples in memory consolidation and decision-making is established in rodent models, our understanding of their role in human memory is incomplete. Here, the authors discuss common methodological challenges in detecting, analyzing, and reporting sharp wave ripples, then they suggest practical solutions to distinguish them from other high-frequency events

    • Anli A. Liu
    • Simon Henin
    • György Buzsáki
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • In response to recommendations to redefine statistical significance to P ≤ 0.005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.

    • Daniel Lakens
    • Federico G. Adolfi
    • Rolf A. Zwaan
    Comments & Opinion
    Nature Human Behaviour
    Volume: 2, P: 168-171

  • Necroptotic cells activate MLKL and release inflammatory DAMPs, although the underlying regulatory mechanisms of this process are poorly understood. Here, Murai et al. develop a necroptosis-specific FRET sensor (SMART) that monitors MLKL membrane translocation to identify two modes of DAMP release.

    • Shin Murai
    • Yoshifumi Yamaguchi
    • Hiroyasu Nakano
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Single-molecule fluorescence resonance energy transfer (smFRET) is applied in live cells and reveals the conformational changes of individual SNARE proteins upon entering a SNARE complex.

    • John J Sakon
    • Keith R Weninger
    Research
    Nature Methods
    Volume: 7, P: 203-205