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Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program

Johanna T. W. Wigman
Ann Ee Ching
John Torous
ResearchOpen Access03 Jun 2025
Schizophrenia

Volume: 11, P: 1-10
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

Understanding the molecular basis of leukaemia predisposition is essential for intervention. The authors here investigate germline genetic leukaemia predisposition by studying Shwachman-Diamond syndrome and report compensatory inactivating mutations in EIF6 and transforming biallelic TP53 alterations.

Alyssa L. Kennedy
Kasiani C. Myers
R. Coleman Lindsley
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-15
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche

Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life.

Friedrich G. Kapp
Julie R. Perlin
Leonard I. Zon
Research13 Jun 2018
Nature

Volume: 558, P: 445-448

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