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Showing 1–12 of 12 results
Advanced filters: Author: John S. Loveday Clear advanced filters

  • Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development and differentiation, and chromosomal segregation.

    • John Pluta
    • Louise C. Pyle
    • Christian Kubisch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • A genome-wide association study of mosaic loss of chromosome Y (LOY) in UK Biobank participants identifies 156 genetic determinants of LOY, showing that LOY is associated with cancer and non-haematological health outcomes.

    • Deborah J. Thompson
    • Giulio Genovese
    • John R. B. Perry
    Research
    Nature
    Volume: 575, P: 652-657

  • Water’s phase diagram exhibits several hydrogen-disordered phases which become ordered upon cooling, but the behavior of ice VI is still debated. The authors, using high-pressure neutron diffraction, identify structural distortions that transform ice VI into ice XIX, here identified as a hydrogen disordered phase.

    • Christoph G. Salzmann
    • John S. Loveday
    • Craig L. Bull
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7

  • Icy moons exhibit thin oxygen atmospheres, but the penetration depth of oxygen-bearing ices and their structures remain unclear. Here, the authors show that oxygen hydrates are able to penetrate deep into icy moons despite the high-pressure interior and identify four phases in the oxygen–water system under icy moon conditions.

    • Mungo Frost
    • Mikhail A. Kuzovnikov
    • Eugene Gregoryanz
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-7

  • Rare truncating mutations in the p53-inducible protein phosphatase PPM1D are shown to be associated with predisposition to breast cancer and ovarian cancer; notably, all of the mutations are mosaic in white blood cells but are not present in tumours, and probably have a gain-of-function effect.

    • Elise Ruark
    • Katie Snape
    • Nazneen Rahman
    Research
    Nature
    Volume: 493, P: 406-410

  • Rajasekhar Suragani et al. show that a modified activin receptor IIB ligand trap increases red blood cell numbers in mice, rats and monkeys and ameliorates anemia in mice and rats, including in a mouse model of myelodysplastic syndromes. The ligand trap binds to the cytokine GDF11 and acts by inhibiting Smad2/3 signaling, thereby reversing ineffective erythropoiesis. Also in this issue, Michael Dussiot et al. show related findings using a wild-type activin receptor IIA ligand trap.

    • Rajasekhar N V S Suragani
    • Samuel M Cadena
    • Ravindra Kumar
    Research
    Nature Medicine
    Volume: 20, P: 408-414

  • Solid ammonium fluoride has fascinating structural similarities with water ice, despite its ionic character. Here, the authors investigate NH4F at room temperature and high pressure, and report a new tetragonal phase formed through displacive transition of fluorine ions and subsequent rotation of ammonium ions in ‘antiferromagnetic’ units at ~115 GPa, which is unlike any form of ice.

    • Umbertoluca Ranieri
    • Christophe Bellin
    • Livia E. Bove
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-8