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Showing 251–296 of 296 results

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Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
To do no harm — and the most good — with AI in health care

Drawing from real-life scenarios and insights shared at the RAISE (Responsible AI for Social and Ethical Healthcare) conference, we highlight the critical need for AI in health care (AIH) to primarily benefit patients and address current shortcomings in health care systems such as medical errors and access disparities.

Carey Beth Goldberg
Laura Adams
Jianfei Zhao
Comments & Opinion22 Feb 2024
Nature Medicine

Volume: 30, P: 623-627
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

Samantha Cruz Rivera
Xiaoxuan Liu
Samuel Rowley
ReviewsOpen Access09 Sept 2020
Nature Medicine

Volume: 26, P: 1351-1363
Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension

The CONSORT-AI and SPIRIT-AI extensions improve the transparency of clinical trial design and trial protocol reporting for artificial intelligence interventions.

Xiaoxuan Liu
Samantha Cruz Rivera
Samuel Rowley
ReviewsOpen Access09 Sept 2020
Nature Medicine

Volume: 26, P: 1364-1374
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang
Molei Liu
Katherine P. Liao
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Genome variation and evolution of the malaria parasite Plasmodium falciparum

Daniel C Jeffares
Arnab Pain
Matthew Berriman
Research10 Dec 2006
Nature Genetics

Volume: 39, P: 120-125
Oral anticoagulants for Asian patients with atrial fibrillation

Asian individuals have a higher risk of stroke associated with atrial fibrillation (AF) than white patients. The use of the vitamin K antagonist warfarin is low in Asian countries, owing to the challenge of controlling anticoagulation and the high-risk of haemorrhage with warfarin in Asians. The non-vitamin K antagonist, oral anticoagulant drugs offer a solution to these challenges. In this article, Sabir et al. discuss the use of these agents in the management of AF in Asian populations.

Ian Sabir
Kaivan Khavandi
A. John Camm
Reviews11 Mar 2014
Nature Reviews Cardiology

Volume: 11, P: 290-303
SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode

This manuscript investigates the binding mode of a potent SARS-CoV-2 neutralizing antibody. N3-1 is escaped by Omicron variants due to altered spike dynamics. This work suggests the need for innovative vaccine designs to combat evolving variants.

Jule Goike
Ching-Lin Hsieh
Jimmy D. Gollihar
ResearchOpen Access11 Dec 2023
Communications Biology

Volume: 6, P: 1-13
A unifying motor control framework for task-specific dystonia

Sadnicka and colleagues present task-specific dystonia in the context of motor skill learning in health. Their framework integrates established risk factors for task-specific dystonia with mechanisms of motor skill learning, to indicate how disrupted neural representations of motor skills might arise.

Anna Sadnicka
Katja Kornysheva
Mark J. Edwards
Reviews06 Nov 2017
Nature Reviews Neurology

Volume: 14, P: 116-124
DICER1: mutations, microRNAs and mechanisms

Germline mutations inDICER1 can lead to DICER1 syndrome, which is characterized by the predisposition of various types of cancer in childhood and during early adulthood. Additionally, specific DICER1 mutations occur in tumours. This Review discusses germline and somatically-acquired DICER1mutations and their effects on tumorigenesis.

William D. Foulkes
John R. Priest
Thomas F. Duchaine
Reviews01 Sept 2014
Nature Reviews Cancer

Volume: 14, P: 662-672
Acute kidney injury: what's the prognosis?

Acute kidney injury (AKI) is common, especially in the critically ill, and is a serious condition associated with substantial morbidity and mortality. In this Review, Murugan and Kellum discuss the epidemiology and prognosis of critically ill patients with AKI as well as describe the role of AKI criteria, biomarkers and therapy on patient outcomes.

Raghavan Murugan
John A. Kellum
Reviews22 Feb 2011
Nature Reviews Nephrology

Volume: 7, P: 209-217
Metabolic reprogramming and tolerance during sepsis-induced AKI

Decreasing susceptibility to tissue damage — a protective strategy known as tolerance — might be as important as infection resistance in determining outcomes in sepsis. Here, the authors discuss tolerance mechanisms that act in the kidney during sepsis, with a focus on the role of metabolic reprogramming.

Hernando Gómez
John A. Kellum
Claudio Ronco
Reviews16 Jan 2017
Nature Reviews Nephrology

Volume: 13, P: 143-151
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
Homologous recombination DNA repair defects in PALB2-associated breast cancers

Anqi Li
Felipe C. Geyer
Mary Anne Young
ResearchOpen Access08 Aug 2019
npj Breast Cancer

Volume: 5, P: 1-14
Letter

Tom Eke
John R Thompson
Correspondence01 Nov 1999
Eye

Volume: 13, P: 810-811
Brain tumour microstructure is associated with post-surgical cognition

Maite Aznarez-Sanado
Rafael Romero-Garcia
John Suckling
ResearchOpen Access07 Mar 2024
Scientific Reports

Volume: 14, P: 1-15
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

Audrey E. Hendricks
Elena G. Bochukova
Hou-Feng Zheng
ResearchOpen Access29 Jun 2017
Scientific Reports

Volume: 7, P: 1-14
KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

Liberalis Debraj Boila
Subhadeep Ghosh
Amitava Sengupta
Research31 Jan 2023
Leukemia

Volume: 37, P: 751-764
Zero-tolerance biosecurity protects high-conservation-value island nature reserve

John K. Scott
Simon J. McKirdy
Kerrie Mengersen
ResearchOpen Access10 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Establishing human lacrimal gland cultures from biopsy-sized tissue specimens

Luke A. Halliday
John P. M. Wood
Michelle T. Sun
Research10 Jan 2022
Eye

Volume: 37, P: 62-68
Close-kin mark-recapture informs critically endangered terrestrial mammal status

Luke R. Lloyd-Jones
Mark V. Bravington
David A. Westcott
ResearchOpen Access02 Aug 2023
Scientific Reports

Volume: 13, P: 1-16
A multiscalar methodology for holistic analysis of prehistoric rock carvings in Scotland

Tertia Barnett
Joana Valdez-Tullett
Guillaume Robin
ResearchOpen Access12 Mar 2024
Heritage Science

Volume: 12, P: 1-35
A dataset of Antarctic ecosystems in ice-free lands: classification, descriptions, and maps

Anikó B. Tóth
Aleks Terauds
David A. Keith
ResearchOpen Access22 Jan 2025
Scientific Data

Volume: 12, P: 1-16
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Lakis et al. report novel findings related to the epigenetic landscape of pancreatic neuroendocrine cancer. This relatively large cohort provides functional insights into the epigenetic wiring of pancreatic neuroendocrine tumor sub-types with the potential ability to stratify tumours of different prognosis.

Vanessa Lakis
Rita T. Lawlor
Aldo Scarpa
ResearchOpen Access03 Feb 2021
Communications Biology

Volume: 4, P: 1-11
The impact of RHDV-K5 on rabbit populations in Australia: an evaluation of citizen science surveys to monitor rabbit abundance

Tarnya E. Cox
David S. L. Ramsey
Peter Elsworth
ResearchOpen Access23 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
Ambient, indoor and personal exposure relationships of volatile organic compounds in Mexico City Metropolitan Area

Paulina I Serrano-Trespalacios
Louise Ryan
John D Spengler
Research30 Apr 2004
Journal of Exposure Science & Environmental Epidemiology

Volume: 14, P: S118-S132
Current best practice for disease activity assessment in IBD

Objective assessment of disease activity in IBD is crucial for successfully guiding therapy. Here, the authors comprehensively evaluate disease activity indices for their use in clinical practice and clinical trials, as well as assessing relevant biomarkers and measures of quality of life.

Alissa J. Walsh
Robert V. Bryant
Simon P. L. Travis
Reviews01 Sept 2016
Nature Reviews Gastroenterology & Hepatology

Volume: 13, P: 567-579
The production of recombinant pharmaceutical proteins in plants

Julian K-C. Ma
Pascal M. W. Drake
Paul Christou
Reviews01 Oct 2003
Nature Reviews Genetics

Volume: 4, P: 794-805
High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation

Anna Sadnicka
Anna Stevenson
Joseph M. Galea
ResearchOpen Access26 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

Andrew T. McKenzie
Minghui Wang
Bin Zhang
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-19
Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers

Jessica M. Logan
Carmela Martini
Ben S.-Y. Ung
ResearchOpen Access08 Aug 2024
Scientific Data

Volume: 11, P: 1-10
Rheotaxis in the Ediacaran epibenthic organism Parvancorina from South Australia

John R. Paterson
James G. Gehling
Russell D. C. Bicknell
ResearchOpen Access30 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
A new approach towards biomarker selection in estimation of human exposure to chiral chemicals: a case study of mephedrone

Erika Castrignanò
Marie Mardal
Barbara Kasprzyk-Hordern
ResearchOpen Access02 Nov 2017
Scientific Reports

Volume: 7, P: 1-12
Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice

Travis C. Jackson
C. Edward Dixon
Patrick M. Kochanek
ResearchOpen Access08 May 2018
Scientific Reports

Volume: 8, P: 1-14
Effect of prolonged freezing of semen on exosome recovery and biologic activity

Jennifer L. Welch
Marisa N. Madison
Chioma M. Okeoma
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
The influence of physicochemical properties on the internal dose of trihalomethanes in humans following a controlled showering exposure

Lalith K Silva
Lorraine C Backer
Benjamin C Blount
Research25 Jul 2012
Journal of Exposure Science & Environmental Epidemiology

Volume: 23, P: 39-45
Publisher Correction: A new approach towards biomarker selection in estimation of human exposure to chiral chemicals: a case study of mephedrone

Erika Castrignanò
Marie Mardal
Barbara Kasprzyk-Hordern
Amendments and CorrectionsOpen Access06 Mar 2018
Scientific Reports

Volume: 8, P: 1
Publisher Correction: A new approach towards biomarker selection in estimation of human exposure to chiral chemicals: a case study of mephedrone

Erika Castrignanò
Marie Mardal
Barbara Kasprzyk-Hordern
Amendments and CorrectionsOpen Access22 Dec 2017
Scientific Reports

Volume: 7, P: 1
Painted plaster and glazed brick fragments from Achaemenid Pasargadae and Persepolis, Iran

Emily Aloiz
Janet G. Douglas
Alexander Nagel
articlesOpen Access19 Feb 2016
Heritage Science

Volume: 4, P: 1-10
A database of chlorophyll a in Australian waters

Claire H. Davies
Penelope Ajani
Anthony J. Richardson
ResearchOpen Access20 Feb 2018
Scientific Data

Volume: 5, P: 1-8
Author Correction: Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

Andrew T. McKenzie
Minghui Wang
Bin Zhang
Amendments and CorrectionsOpen Access24 Sept 2021
Scientific Reports

Volume: 11, P: 1-4
Publisher Correction: Homologous recombination DNA repair defects in PALB2-associated breast cancers

Anqi Li
Felipe C. Geyer
Jorge S. Reis-Filho
Amendments and CorrectionsOpen Access19 Nov 2019
npj Breast Cancer

Volume: 5, P: 1
IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo

Peter K M Kim
Michaele Armstrong
John H Yim
Research05 Feb 2004
Oncogene

Volume: 23, P: 1125-1135
Comment on “Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis”

Rama Jayaraj
Peter Shaw
Siddhartha Baxi
Correspondence12 Apr 2021
British Journal of Cancer

Volume: 124, P: 1891-1892

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