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Showing 1–4 of 4 results
Advanced filters: Author: Johnna Doherty Clear advanced filters

  • During Wallerian degeneration of Drosophila axons, Draper and Crk/Mbc/dCed-12 signaling non-redundantly promote clearance of axonal debris. Draper signaling is required early to activate glial responses to axonal injury, whereas Crk/Mbc/dCed-12 are dispensable for glial activation, but are essential at the phagocytic step for internalization and degradation of axonal debris.

    • Jennifer S Ziegenfuss
    • Johnna Doherty
    • Marc R Freeman
    Research
    Nature Neuroscience
    Volume: 15, P: 979-987

  • In this Review, Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival and cell death. They cover the interplay between autophagy, apoptosis and necrosis, as well as engulfment and inflammation.

    • Johnna Doherty
    • Eric H. Baehrecke
    Reviews
    Nature Cell Biology
    Volume: 20, P: 1110-1117

  • The engulfment receptor Draper is known to promote glial clearance of degenerating neurons in Drosophila, and this action of Draper is mediated by Src kinase. This study now shows that one of three Draper isoforms, namely Draper-II, negatively regulates glial clearance and acts in opposition to pro-clearance Draper-I.

    • Mary A Logan
    • Rachel Hackett
    • Marc R Freeman
    Research
    Nature Neuroscience
    Volume: 15, P: 722-730