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Showing 1–2 of 2 results
Advanced filters: Author: Jon D Gaffaney Clear advanced filters

  • Synaptotagmin-1 aggregates membranes in response to Ca2+. Using a variety of approaches, it was discovered that synaptotagmin-mediated membrane aggregation occurs through trans interactions between synaptotagmin molecules bound to different membranes. Synaptotagmin-regulated, SNARE-catalyzed fusion further requires synaptotagmin to drive the assembly of nonfusogenic syntaxin and SNAP25 into fusion-competent t-SNARE heterodimers.

    • Enfu Hui
    • Jon D Gaffaney
    • Edwin R Chapman
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 813-821

  • This study demonstrates a direct role for synaptotagmin I in the endocytosis of synaptic vesicles that is distinct from its role in exocytosis. In addition, the authors find that either of the C2 domains of syt1 can act as a calcium sensor during endocytosis.

    • Jun Yao
    • Sung E Kwon
    • Edwin R Chapman
    Research
    Nature Neuroscience
    Volume: 15, P: 243-249