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Showing 1–5 of 5 results
Advanced filters: Author: Jonas Binz Clear advanced filters

  • In this Perspective article, Huwyler, Binz and colleagues discuss the future of long-term normothermic machine perfusion for livers and propose a staged assessment approach for ex situ perfused organs.

    • Florian Huwyler
    • Jonas Binz
    • Pierre-Alain Clavien
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 721-733

  • Ding et al. find a mechanism coordinating fatty acid and glucose supply. Glucose-driven Golgi phosphatidylinositol 4-phosphate levels impact the assembly of E3 ligase complex CUL7–FBXW8, controlling adipose triglyceride lipase levels and lipolysis.

    • Lianggong Ding
    • Florian Huwyler
    • Christian Wolfrum
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 552-566

  • A detailed understanding of the catalytic target DNA cleavage mechanism by CRISPR–Cas9 has been lacking. Now the key modulating role of Mg2+ in the conformational activation of Cas9 and the influence of active site residues on the protonation state of catalytic H840 are demonstrated, ultimately unravelling the catalytic mechanism.

    • Łukasz Nierzwicki
    • Kyle W. East
    • Giulia Palermo
    Research
    Nature Catalysis
    Volume: 5, P: 912-922

  • A structural model of a K-Ras nanocluster that promotes the stability and accessibility of active K-Ras and creates composite interfaces that facilitate Raf binding provides a framework to unravel MAPK signaling.

    • Venkatesh P. Mysore
    • Zhi-Wei Zhou
    • David E. Shaw
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 847-857