Nature Search

Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Differential expansion of T central memory precursor and effector subsets is regulated by division speed

T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on antigenic rather than inflammatory stimuli to maintain their cell cycle speed.

Lorenz Kretschmer
Michael Flossdorf
Veit R. Buchholz
ResearchOpen Access08 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Complications, functional and quality of life outcomes following primary and secondary implantation of penile prosthesis at a tertiary referral center

Bernhard Ralla
Irena Goranova
Jonas Busch
Research04 Dec 2017
International Journal of Impotence Research

Volume: 30, P: 49-53
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells

Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a diversity of fate types resulting from the intrinsic variability among the clonal population before treatment.

Yogesh Goyal
Gianna T. Busch
Arjun Raj
Research19 Jul 2023
Nature

Volume: 620, P: 651-659
A multi-marker association method for genome-wide association studies without the need for population structure correction

Currently available methods for phenotype to genetic markers association need to account for population structure. Here, Klasen et al. devise a statistical method called Quantitative Trait Cluster Association Test (QTCAT) that overcomes the need for population structure correction.

Jonas R. Klasen
Elke Barbez
Korbinian Schneeberger
ResearchOpen Access10 Nov 2016
Nature Communications

Volume: 7, P: 1-8
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection

T cell memory formation is often described as occurring during the chronic phases of infection. Buchholz and colleagues use the phenomenon of ‘memory inflation’ following cytomegalovirus infection to show that a tiny subset of self-renewing T cells branch off early from the bulk population to generate memory.

Simon Grassmann
Lorenz Mihatsch
Veit R. Buchholz
Research26 Oct 2020
Nature Immunology

Volume: 21, P: 1563-1573
The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

A novel study led by scientists in Lübeck, Germany, shows that SARS-CoV-2-infected brain endothelial cells undergo cell death due to the cleavage of NEMO by the viral protease M^pro, potentially causing cerebral COVID-19 and ‘long COVID’ symptoms.

Jan Wenzel
Josephine Lampe
Markus Schwaninger
ResearchOpen Access21 Oct 2021
Nature Neuroscience

Volume: 24, P: 1522-1533
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blocked by the concomitant inhibition of the NOTCH and WNT pathways.

Annika Fendler
Daniel Bauer
Walter Birchmeier
ResearchOpen Access17 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.

Jonas Weinmann
Sabrina Weis
Dirk Grimm
ResearchOpen Access28 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors

Over the past decade, research interest in the functional and regulatory roles of microRNAs, a class of small, non-coding RNAs, has increased dramatically. In this article, the authors provide an overview of the role of microRNAs in urologic tumors, and highlight their potential as diagnostic or prognostic markers of disease and as targets for cancer treatments.

Annika Schaefer
Carsten Stephan
Klaus Jung
Reviews06 Apr 2010
Nature Reviews Urology

Volume: 7, P: 286-297
Oncological outcomes, quality of life outcomes and complications of partial cystectomy for selected cases of muscle-invasive bladder cancer

Jan Ebbing
Robin Colja Heckmann
Carsten Kempkensteffen
ResearchOpen Access30 May 2018
Scientific Reports

Volume: 8, P: 1-19

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