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Showing 1–18 of 18 results
Advanced filters: Author: Jonas Doerr Clear advanced filters

  • Transplantation of cells into the central nervous system has developed into a major avenue for replacing neurons lost to neurodegenerative disease. Here the authors develop an approach combining viral-based transynaptic tracing labeling and whole brain imaging to trace synaptic innervation of human neurons transplanted into a mouse background.

    • Jonas Doerr
    • Martin Karl Schwarz
    • Oliver Brüstle
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

    • Viktoria Cologna
    • Simona Meiler
    • Amber Zenklusen
    ResearchOpen Access
    Nature Climate Change
    Volume: 15, P: 725-735

  • An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.

    • Wen-Wei Liao
    • Mobin Asri
    • Benedict Paten
    ResearchOpen Access
    Nature
    Volume: 617, P: 312-324

  • To increase the efficiency of direct neuronal conversion of postnatal human fibroblasts, the authors combine two-factor neuronal programming with small molecules. This method increases the yield and purity of functional neuron-like cells by more than 15-fold.

    • Julia Ladewig
    • Jerome Mertens
    • Oliver Brüstle
    Research
    Nature Methods
    Volume: 9, P: 575-578

  • Skin tumour array by microporation (STAMP) captures the dynamic relationships of spatial, cellular and molecular components of tumour rejection and has the potential to translate therapeutic concepts into successful clinical strategies.

    • Guadalupe Ortiz-Muñoz
    • Markus Brown
    • Christine Moussion
    ResearchOpen Access
    Nature
    Volume: 618, P: 827-833

  • The Min biochemical network regulates bacterial cell division and is a prototypical example of self-organizing molecular systems. Here authors synthesize Min proteins from their genes inside liposomes and observe dynamic protein patterns and liposome shape deformation.

    • Elisa Godino
    • Jonás Noguera López
    • Christophe Danelon
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Biodiversity protection indicators are important to assess progress towards sustainable development goals. Using mountain ecosystems as an example, this study compared two biodiversity protection reporting metrics varying in their underlying methods and applied at different spatial scales.

    • Amina Ly
    • Jonas Geschke
    • Davnah Urbach
    ResearchOpen Access
    Nature Sustainability
    Volume: 6, P: 1547-1551

  • Fibroblastic reticular cells (FRCs) provide structural support and soluble factors necessary for proper lymph node organization and function. Turley and colleagues use scRNA-seq to identify a unique Gremlin1-expressing FRC subset that is found in T cell zones. Grem1+ FRCs support the survival of resident cDCs and are necessary to promote T cell immunity.

    • Varun N. Kapoor
    • Sören Müller
    • Shannon J. Turley
    Research
    Nature Immunology
    Volume: 22, P: 571-585

  • Comparisons within the human pangenome establish that homologous regions on short arms of heterologous human acrocentric chromosomes actively recombine, leading to the high rate of Robertsonian translocation breakpoints in these regions.

    • Andrea Guarracino
    • Silvia Buonaiuto
    • Erik Garrison
    ResearchOpen Access
    Nature
    Volume: 617, P: 335-343

  • A study comparing the pattern of single-nucleotide variation between unique and duplicated regions of the human genome shows that mutation rate and interlocus gene conversion are elevated in duplicated regions.

    • Mitchell R. Vollger
    • Philip C. Dishuck
    • Evan E. Eichler
    ResearchOpen Access
    Nature
    Volume: 617, P: 325-334

  • Mass spectrometry imaging with fluoromethylpyridinium-based reactive matrices allows mapping of neurotransmitters at high resolution and at a low limit of detection. The approach is applied to rat, macaque and human brain tissue samples for probing Parkinson’s disease-related changes.

    • Mohammadreza Shariatgorji
    • Anna Nilsson
    • Per E. Andrén
    Research
    Nature Methods
    Volume: 16, P: 1021-1028

  • A multi-laboratory study in the form of a community challenge assesses the quality of models that can be produced from cryo-EM maps using different software tools, the reproducibility of models generated by different users and the performance of metrics used for model validation.

    • Catherine L. Lawson
    • Andriy Kryshtafovych
    • Wah Chiu
    ResearchOpen Access
    Nature Methods
    Volume: 18, P: 156-164

  • Godino et al. show that FtsA-FtsZ ring-like structures driven by cell-free gene expression can be reconstituted on planar membranes and inside liposome compartments. These cytoskeletal structures constrict the liposome, generating elongated membrane necks and budding vesicles. This study represents a step forward to realizing genetic programming of synthetic cell division.

    • Elisa Godino
    • Jonás Noguera López
    • Christophe Danelon
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11