Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature Communications (3)
Nature Chemical Biology (2)
Scientific Reports (2)
Cell Research (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (7)
Amendments and Corrections (1)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biophysics
Cardiology
Cell biology
Chemical biology
Chemistry
Drug discovery
Molecular biology
Structural biology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–8 of 8 results

Advanced filters: Author: Jonas Gmeiner Clear advanced filters

Activation of the α_2B adrenoceptor by the sedative sympatholytic dexmedetomidine

A cryo-EM structure of the GPCR α_2B adrenergic receptor (α_2BAR) in complex with the selective agonist dexmedetomidine and the G protein Go suggests a mechanism of selective activation and provides insights into G-protein coupling activity.

Daopeng Yuan
Zhongmin Liu
Brian K. Kobilka
Research09 Mar 2020
Nature Chemical Biology

Volume: 16, P: 507-512
Constrained catecholamines gain β₂AR selectivity through allosteric effects on pocket dynamics

Constrained catecholamines gain β₂AR selectivity. Although the orthosteric pockets are identical in β₁AR and β₂AR, surrounding residues allosterically modify the pockets and contribute to the β₂AR selectivity of the constrained catecholamines.

Xinyu Xu
Jeremy Shonberg
Peter Gmeiner
ResearchOpen Access14 Apr 2023
Nature Communications

Volume: 14, P: 1-13
An allosteric modulator binds to a conformational hub in the β₂ adrenergic receptor

A negative allosteric modulator of the G-protein-coupled receptor β₂-adrenergic receptor binds to a membrane-facing surface adjacent to a molecular switch for receptor activation, and its binding disrupts a water-mediated polar network stabilizing an inactive switch conformation.

Xiangyu Liu
Jonas Kaindl
Peter Gmeiner
Research01 Jun 2020
Nature Chemical Biology

Volume: 16, P: 749-755
Author Correction: Constrained catecholamines gain β₂AR selectivity through allosteric effects on pocket dynamics

Xinyu Xu
Jeremy Shonberg
Peter Gmeiner
Amendments and CorrectionsOpen Access24 May 2023
Nature Communications

Volume: 14, P: 1
Structure-guided development of heterodimer-selective GPCR ligands

G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers

Harald Hübner
Tamara Schellhorn
Peter Gmeiner
ResearchOpen Access26 Jul 2016
Nature Communications

Volume: 7, P: 1-12
Retrospective exploratory dual-center analysis of temporary transvenous cardiac pacing in cardiogenic shock

Clemens Walter von Musil
Valentina Riederer
Clemens Scherer
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Binding pathway determines norepinephrine selectivity for the human β₁AR over β₂AR

Xinyu Xu
Jonas Kaindl
Xiangyu Liu
Research22 Oct 2020
Cell Research

Volume: 31, P: 569-579
Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

Alina Tabor
Siegfried Weisenburger
Peter Gmeiner
ResearchOpen Access12 Sept 2016
Scientific Reports

Volume: 6, P: 1-16