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Showing 1–12 of 12 results
Advanced filters: Author: Jonas Metz Clear advanced filters

  • Haematopoietic stem cells (HSC) are responsible for blood cell generation and reside in the bone marrow. Here, the authors show that macrophages in the bone marrow originate from embryonic or adult haematopoietic lineages and that embryo-derived macrophages are important for the establishment of the HSC pool.

    • Gülce Perçin
    • Konstantin Riege
    • Claudia Waskow
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

    • Sarthak Pati
    • Ujjwal Baid
    • Spyridon Bakas
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Free-electron lasers are capable of high repetition rates and it is assumed that protein crystals often do not survive the first X-ray pulse. Here the authors address these issues with a demonstration of multi-hit serial crystallography in which multiple FEL pulses interact with the sample without destroying it.

    • Susannah Holmes
    • Henry J. Kirkwood
    • Connie Darmanin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • This paper reports the realization of a chromium Bose-Einstein condensate (BEC) with strong anisotropic magnetic dipole–dipole interaction between the atoms, which induces a pronounced change of the aspect ratio of the cloud. The experiment opens the way for exploration of the unique properties of quantum ferrofluids.

    • Thierry Lahaye
    • Tobias Koch
    • Tilman Pfau
    Research
    Nature
    Volume: 448, P: 672-675

  • Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

    • Nick Patterson
    • Michael Isakov
    • David Reich
    Research
    Nature
    Volume: 601, P: 588-594

  • The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at the level of chromatin, mRNA and protein expression.

    • Maikel L. Colli
    • Mireia Ramos-Rodríguez
    • Décio L. Eizirik
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop isoform-selective covalent-allosteric Akt inhibitors

    • Lena Quambusch
    • Laura Depta
    • Daniel Rauh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Genome-wide data from 400 individuals indicate that the initial spread of the Beaker archaeological complex between Iberia and central Europe was propelled by cultural diffusion, but that its spread into Britain involved a large-scale migration that permanently replaced about ninety per cent of the ancestry in the previously resident population.

    • Iñigo Olalde
    • Selina Brace
    • David Reich
    Research
    Nature
    Volume: 555, P: 190-196

  • The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure.

    • Max O. Wiedorn
    • Dominik Oberthür
    • Anton Barty
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11