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Showing 1–10 of 10 results
Advanced filters: Author: Jonas Pollard Clear advanced filters

  • Haematopoietic stem cells (HSC) are responsible for blood cell generation and reside in the bone marrow. Here, the authors show that macrophages in the bone marrow originate from embryonic or adult haematopoietic lineages and that embryo-derived macrophages are important for the establishment of the HSC pool.

    • Gülce Perçin
    • Konstantin Riege
    • Claudia Waskow
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin binding, nor H3K9me3.

    • Iris Müller
    • Ann Sophie Moroni
    • Kristian Helin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • GeSn alloys hold promise for spintronics and quantum computing due to their scalable fabrication and spin manipulation capabilities. Here, the authors study a two-dimensional hole gas in a Ge/GeSn quantum well, revealing enhanced spin-orbit interactions and g-factors, providing key insights for designing GeSn-based spintronic devices.

    • Prateek Kaul
    • Jan Karthein
    • Dan Buca
    ResearchOpen Access
    Communications Materials
    Volume: 6, P: 1-8

  • Methods to diagnose malaria are of interest but can be costly or not sensitive enough to detect low levels of parasitemia. Here the authors report an ultrasensitive method by using hemozoin (a biomarker of all Plasmodium species) to catalyse the polymerization of N-isopropylacrylamide.

    • Omar Rifaie-Graham
    • Jonas Pollard
    • Nico Bruns
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • Although mutant H3K27M histones inhibit PRC2 in diffuse intrinsic pontine gliomas, these tumors exhibit significant amounts of PRC2 activity. The repression of several genes, including INK4A, by residual EZH2 activity is required for tumor growth, and EZH2 inhibitors therefore represent potential therapies for these patients.

    • Faizaan Mohammad
    • Simon Weissmann
    • Kristian Helin
    Research
    Nature Medicine
    Volume: 23, P: 483-492

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • While hundreds of loci are linked with inflammatory bowel diseases (IBDs), the functional consequences of the associated variants remain unclear. Here, the authors screened in ulcerative colitis (UC) patients’ genomes for protein-truncating variants near IBD loci, and identify a protein truncating variant in RNF186to be protective against UC.

    • Manuel A. Rivas
    • Daniel Graham
    • Mark J. Daly
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8