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Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Management of chronic obstructive pulmonary disease (COPD) in primary care: a questionnaire survey in western Sweden

Jörgen Thorn
Maria Norrhall
Cecilia Björkelund
Research05 Mar 2008
Primary Care Respiratory Journal

Volume: 17, P: 26-31
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

In Greenlandic Inuit, a TBC1D4 loss-of-function mutation increases type 2 diabetes risk by tenfold. Carriers show severe muscle insulin resistance, impaired glucose disposal and reduced muscle GLUT4, yet exercise mitigates these defects, offering potential for personalized lifestyle interventions.

Jonas M. Kristensen
Rasmus Kjøbsted
Jørgen F. P. Wojtaszewski
ResearchOpen Access31 Oct 2024
Nature Metabolism

Volume: 6, P: 2254-2266
An in situ depot for the sustained release of a TLR7/8 agonist in combination with a TGFβ inhibitor promotes anti-tumor immune responses

Co-delivery of TLR7/8 agonists and TGF-β inhibitors (TGFβi) has the potential to overcome immunosuppression in the tumor microenvironment. Here the authors describe the application of the CarboCell technology for the sustained intratumoral release of a TLR7/8 agonist alone or in combination with a TGFβi, promoting anti-tumor immune responses in preclinical cancer models.

Sophie B. Jensen
Ditte E. Jæhger
Thomas L. Andresen
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Proteomic profiling of neonatal herpes simplex virus infection on dried blood spots

Dungu et al. use high throughput multiplexed proteomics on dried blood spot samples from neonates with herpes simplex virus infection. Distinct protein profiles were seen in proteins associated with innate and adaptive immune responses neonates with disseminated HSV disease compared to controls.

Kia Hee Schultz Dungu
Christian Munch Hagen
Jonas Bybjerg-Grauholm
ResearchOpen Access18 Dec 2024
Communications Medicine

Volume: 4, P: 1-8
An intranasal cationic liposomal polysaccharide vaccine elicits humoral immune responses against Streptococcus pneumoniae

Intranasal immunization with capsular pneumococcal polysaccharides 12F and iNKT agonist α-galactosylceramide in cationic liposomes protects mice from S. pneumoniae 12F infection.

Peng Wei
Cecilia Romanò
Mads H. Clausen
ResearchOpen Access17 Sept 2024
Communications Biology

Volume: 7, P: 1-11
Enhancing adoptive CD8 T cell therapy by systemic delivery of tumor associated antigens

Ditte E. Jæhger
Mie L. Hübbe
Thomas L. Andresen
ResearchOpen Access05 Oct 2021
Scientific Reports

Volume: 11, P: 1-19
Design, calibration and application of broad-range optical nanosensors for determining intracellular pH

This protocol describes the preparation and application of a polymer-based nanosensor that combines the two pH-sensitive fluorophores fluorescein and Oregon Green for imaging intracellular pH (pH 3.1–7.0).

Rikke V Søndergaard
Jonas R Henriksen
Thomas L Andresen
Protocols20 Nov 2014
Nature Protocols

Volume: 9, P: 2841-2858
Wild harbour porpoises startle and flee at low received levels from acoustic harassment device

Siri L. Elmegaard
Jonas Teilmann
Peter Teglberg Madsen
ResearchOpen Access04 Oct 2023
Scientific Reports

Volume: 13, P: 1-15
High prevalence of biofilm synergy among bacterial soil isolates in cocultures indicates bacterial interspecific cooperation

Dawei Ren
Jonas S Madsen
Mette Burmølle
Research17 Jun 2014
The ISME Journal

Volume: 9, P: 81-89

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Polygenic prediction of body mass index and obesity through the life course and across ancestries

A saturated map of common genetic variants associated with human height

Management of chronic obstructive pulmonary disease (COPD) in primary care: a questionnaire survey in western Sweden

Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

An in situ depot for the sustained release of a TLR7/8 agonist in combination with a TGFβ inhibitor promotes anti-tumor immune responses

Proteomic profiling of neonatal herpes simplex virus infection on dried blood spots

An intranasal cationic liposomal polysaccharide vaccine elicits humoral immune responses against Streptococcus pneumoniae

Enhancing adoptive CD8 T cell therapy by systemic delivery of tumor associated antigens

Design, calibration and application of broad-range optical nanosensors for determining intracellular pH

Wild harbour porpoises startle and flee at low received levels from acoustic harassment device

High prevalence of biofilm synergy among bacterial soil isolates in cocultures indicates bacterial interspecific cooperation

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