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Showing 1–4 of 4 results
Advanced filters: Author: Jonas Wanninger Clear advanced filters

  • Extensive mutational analyses of ferroptosis suppressor protein-1 (FSP1) reveal its molecular mechanism in ferroptosis prevention and uncover the mechanism of action of the FSP1 inhibitor iFSP1 and a new species-independent FSP1 inhibitor, viFSP1.

    • Toshitaka Nakamura
    • Eikan Mishima
    • Marcus Conrad
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1806-1815

  • An inhibitor of the ferroptosis-suppressing FSP1 induces phase separation of FSP1, thereby impairing its function and reducing tumour growth.

    • Toshitaka Nakamura
    • Clara Hipp
    • Marcus Conrad
    ResearchOpen Access
    Nature
    Volume: 619, P: 371-377

  • Biochemical and lipidomic analyses identify an anti-ferroptotic function of vitamin K and reveal ferroptosis suppressor protein 1 (FSP1) as the enzyme mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle.

    • Eikan Mishima
    • Junya Ito
    • Marcus Conrad
    ResearchOpen Access
    Nature
    Volume: 608, P: 778-783

  • In the absence of GPX4, FSP1 regenerates ubiquinol from the oxidized form, ubiquinone, using NAD(P)H and suppresses phospholipid peroxidation and ferroptosis in cells.

    • Sebastian Doll
    • Florencio Porto Freitas
    • Marcus Conrad
    Research
    Nature
    Volume: 575, P: 693-698