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Showing 1–4 of 4 results

Advanced filters: Author: Jonathan C Charest Clear advanced filters

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

A high-throughput screen identifies NGI-1 as an inhibitor of oligosaccharyltransferase, preventing transfer of N-linked glycans to proteins. NGI-1 blocked EGFR signaling in non-small-cell lung cancer cell lines and promoted cell-cycle arrest and senescence.

Cecilia Lopez-Sambrooks
Shiteshu Shrimal
Joseph N Contessa
Research03 Oct 2016
Nature Chemical Biology

Volume: 12, P: 1023-1030
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Kevin M Haigis
Krystle R Kendall
Tyler Jacks
Research30 Mar 2008
Nature Genetics

Volume: 40, P: 600-608
Measurement of oxygen consumption rates of human renal proximal tubule cells in an array of organ-on-chip devices to monitor drug-induced metabolic shifts

Samuel H. Kann
Erin M. Shaughnessey
Joseph L. Charest
ResearchOpen Access29 Sept 2022
Microsystems & Nanoengineering

Volume: 8, P: 1-12
Perfusion decellularization of whole organs

This describes how to decellularize whole organs using pressure-controlled perfusion, which enables preparation of acellular 3D scaffolds with preserved extracellular membrane protein content, organ architecture and perfusable vascular conduits.

Jacques P Guyette
Sarah E Gilpin
Harald C Ott
Protocols29 May 2014
Nature Protocols

Volume: 9, P: 1451-1468