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Showing 1–4 of 4 results
Advanced filters: Author: Jonathan C. Grima Clear advanced filters

  • A candidate-based genetic screen in Drosophila expressing 30 G4C2-repeat-containing RNAs finds that RanGAP, a key regulator of nucleocytoplasmic transport, is a potent suppressor of neurodegeneration; the defects caused by the G4C2 repeat expansions can be rescued with antisense oligonucleotides or small molecules targeting the G-quadruplexes.

    • Ke Zhang
    • Christopher J. Donnelly
    • Jeffrey D. Rothstein
    Research
    Nature
    Volume: 525, P: 56-61

  • Mitochondrial dysfunction has been associated with Parkinson’s disease but effective therapies targeting this pathway are yet to be developed. Here the authors show that inhibition of the mitochondrial fission protein Drp-1 using genetic or small-molecule approaches in mouse models of the disease, leads to improvements in the pathology.

    • Phillip M. Rappold
    • Mei Cui
    • Kim Tieu
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-13

  • Zhang et al. show that the poly(GA) proteins produced in patients with C9ORF72 repeat expansions cause neurodegeneration and behavioral abnormalities when expressed in mice. The emergence of these phenotypes requires poly(GA) aggregation, and poly(GA) inclusions sequester HR23 proteins involved in proteasomal degradation, as well as proteins involved in nucleocytoplasmic transport.

    • Yong-Jie Zhang
    • Tania F Gendron
    • Leonard Petrucelli
    Research
    Nature Neuroscience
    Volume: 19, P: 668-677

  • Oaks can live hundreds of years. Comparative genomics using a high-quality genome sequence provides new insights that may explain tree longevity. Samples from branches and corresponding acorns also help quantify heritable somatic mutations.

    • Christophe Plomion
    • Jean-Marc Aury
    • Jérôme Salse
    ResearchOpen Access
    Nature Plants
    Volume: 4, P: 440-452