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GDF15 links adipose tissue lipolysis with anxiety

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Logan K. Townsend
Dongdong Wang
Gregory R. Steinberg
ResearchOpen Access15 Apr 2025
Nature Metabolism

Volume: 7, P: 1004-1017
Author Correction: Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice

Yun Han Kwon
Suhrid Banskota
Waliul I. Khan
Amendments and CorrectionsOpen Access30 May 2023
Nature Communications

Volume: 14, P: 1
Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice

Allura Red AC is a dye used in food products. Here the authors report that chronic, long-term exposure to Allura Red AC increases susceptibility to experimental colitis in mice dependent on the serotonin biosynthetic enzyme TPH1, while intermittent exposure more typical for the human setting did not increase susceptibility to experimental colitis.

Yun Han Kwon
Suhrid Banskota
Waliul I. Khan
ResearchOpen Access20 Dec 2022
Nature Communications

Volume: 13, P: 1-18
Long term but not short term exposure to obesity related microbiota promotes host insulin resistance

Gut microbiota impact host metabolism and gut microbiome composition reflects dietary habits. Here the authors show that, in animals fed obesogenic diets, changes in gut microbiota precede changes in glucose homeostasis. Importantly, long term exposure of the host to the changed microbiota is required to impair glucose homeostasis.

Kevin P. Foley
Soumaya Zlitni
Jonathan D. Schertzer
ResearchOpen Access08 Nov 2018
Nature Communications

Volume: 9, P: 1-15
Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity

Anhê et al. demonstrate that bacterial signatures of plasma, liver and three distinct adipose tissue depots can distinguish between type 2 diabetes and normoglycaemia in people with obesity.

Fernando F. Anhê
Benjamin Anderschou Holbech Jensen
André Marette
Research09 Mar 2020
Nature Metabolism

Volume: 2, P: 233-242
Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants

Jennifer C. Stearns
Julia Simioni
Eileen K. Hutton
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
Risk of Infection and Sepsis in Pediatric Patients with Traumatic Brain Injury Admitted to Hospital Following Major Trauma

Anjli Pandya
Kathleen Helen Chaput
Graham C. Thompson
ResearchOpen Access28 Jun 2018
Scientific Reports

Volume: 8, P: 1-6
Bacteria to alleviate metabolic syndrome

Heat-inactivated Akkermansia muciniphila helps alleviate features of metabolic syndrome in overweight and obese subjects.

Fernando F. Anhê
Jonathan D. Schertzer
André Marette
News & Views01 Jul 2019
Nature Medicine

Volume: 25, P: 1031-1033
Bacteria transmit metformin-associated lifespan extension

Metformin is the mainstay therapy for type 2 diabetes mellitus. A new study shows that metformin acts directly on gut bacteria to elevate cAMP-induced agmatine production, thereby increasing lipid metabolism and lifespan in model organisms. These data identify links between metformin and gut microbiota that might be important for increasing longevity.

Lesley T. MacNeil
Jonathan D. Schertzer
Gregory R. Steinberg
News & Views23 Oct 2019
Nature Reviews Endocrinology

Volume: 16, P: 9-10
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

Elevated eripheral serotonin reduces brown adipose tissue thermogenesis and promotes obesity and metabolic dysfunction.

Justin D Crane
Rengasamy Palanivel
Gregory R Steinberg
Research08 Dec 2014
Nature Medicine

Volume: 21, P: 166-172
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Metformin is one of the most widely prescribed therapeutics for type 2 diabetes. But exactly how it works is still unclear. Gregory Steinberg and colleagues now show that it does so by activation of the enzyme AMP-activated protein kinase (Ampk) and Ampk's obligate targeting of two key enzymes involved in lipid homeostasis.

Morgan D Fullerton
Sandra Galic
Gregory R Steinberg
Research03 Nov 2013
Nature Medicine

Volume: 19, P: 1649-1654
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

Increasing the expression of intramuscular heat shock protein 72 preserves muscle strength and ameliorates the dystrophic pathology in two mouse models of muscular dystrophy, suggesting a promising way forward for the treatment of muscular dystrophy.

Stefan M. Gehrig
Chris van der Poel
Gordon S. Lynch
Research04 Apr 2012
Nature

Volume: 484, P: 394-398
Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia

Brittany M. Duggan
Kevin P. Foley
Jonathan D. Schertzer
ResearchOpen Access08 May 2017
Scientific Reports

Volume: 7, P: 1-13
Correction To: Associations of intrapartum antibiotics and growth, atopy, gastrointestinal and sleep outcomes at one year of age

Eileen K. Hutton
Julia C. Simioni
Katherine M. Morrison
Amendments and Corrections09 Jun 2023
Pediatric Research

Volume: 94, P: 1251
Associations of intrapartum antibiotics and growth, atopy, gastrointestinal and sleep outcomes at one year of age

Eileen K. Hutton
Julia C. Simioni
Katherine M. Morrison
Research18 Feb 2023
Pediatric Research

Volume: 94, P: 1026-1034

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