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Showing 1–6 of 6 results
Advanced filters: Author: Jonathan Dworkin Clear advanced filters
  • Many bacterial species shut down metabolism and enter a dormant state in order to survive in unfavourable conditions. Exit from dormancy in response to cell wall muropeptide signals from neighbouring cells has recently been observed forBacillus subtilisspores. In this Opinion article, Dworkin and Shah propose that this might be a more general phenomenon.

    • Jonathan Dworkin
    • Ishita M. Shah
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 890-896
  • Bacterial cell shape is dependent on the formation of the extracellular sugar polymer called peptidoglycan. Here the authors describe RodA-PBP2, the enzymatic core of the elongasome, which is the complex responsible peptidoglycan synthesis, and utilize an integrated approach to investigate the mechanism of peptidoglycan biosynthesis.

    • Rie Nygaard
    • Chris L. B. Graham
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • Individual bacteria within isogenic populations can differ in antibiotic tolerance. Here, Libby et al. show that antibiotic tolerance variability can be driven by ‘noisy’ expression of a gene encoding a (p)ppGpp synthetase, which is in turn regulated by multisite phosphorylation of a transcription factor.

    • Elizabeth A. Libby
    • Shlomi Reuveni
    • Jonathan Dworkin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • A study shows that water can control macroscopic properties of biological materials through the hydration force, giving rise to a distinct class of solid matter with unusual properties.

    • Steven G. Harrellson
    • Michael S. DeLay
    • Ozgur Sahin
    Research
    Nature
    Volume: 619, P: 500-505
  • Individuals with exactly the same genetic make-up can differ from one another in their development and resulting phenotype when the genome contains a mutation — a phenomenon called 'partial penetrance'. Exploration of the genetic and stochastic factors controlling the proportion of abnormal 'twin' spores in mutant populations of the bacterium Bacillus subtilus now reveals how mutations affecting DNA replication and cell division may act in synergy to significantly increase the penetrance of twin sporulation.

    • Avigdor Eldar
    • Vasant K. Chary
    • Michael B. Elowitz
    Research
    Nature
    Volume: 460, P: 510-514