Nature Search

On the magnetization and origin of the millisecond pulsar 1937 + 214

Jonathan Arons
Research24 Mar 1983
Nature

Volume: 302, P: 301-305
Reconstitution of a phospholipid flippase from rat liver microsomes

Jonathan M. Backer
Eliezar A. Dawidowicz
Research28 May 1987
Nature

Volume: 327, P: 341-343
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao Jian Sun
Paul Rothenberg
Morris F White
Research04 Jul 1991
Nature

Volume: 352, P: 73-77
Defective acidification of intracellular organelles in cystic fibrosis

Jonathan Barasch
Brian Kiss
Qais AI-Awqati
Research04 Jul 1991
Nature

Volume: 352, P: 70-73
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

Wiebe Kruijer
Jonathan A. Cooper
Inder M. Verma
Research20 Dec 1984
Nature

Volume: 312, P: 711-716
Suppression of an amber mutation by microinjection of suppressor tRNA in C. elegans

Judith Kimble
Jonathan Hodgkin
John Smith
Research30 Sept 1982
Nature

Volume: 299, P: 456-458
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism.

Benoit Bilanges
Samira Alliouachene
Bart Vanhaesebroeck
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost

Here the authors analyze data from COVAIL trial participants receiving an mRNA second COVID-19 vaccine boost and show that, while neutralizing antibody titer is correlated with Omicron COVID-19 risk, the correlation is weak in naïve individuals compared to previously infected ones.
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Bo Zhang
Youyi Fong
Dean Follmann
ResearchOpen Access17 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences

Randomised controlled experiments are the gold standard for scientific inference, but environmental and social scientists often rely on different study designs. Here the authors analyse the use of six common study designs in the fields of biodiversity conservation and social intervention, and quantify the biases in their estimates.

Alec P. Christie
David Abecasis
William J. Sutherland
ResearchOpen Access11 Dec 2020
Nature Communications

Volume: 11, P: 1-11
Phosphatidylinositol-3-OH kinases are Rab5 effectors

Savvas Christoforidis
Marta Miaczynska
Marino Zerial
Research15 Jul 1999
Nature Cell Biology

Volume: 1, P: 249-252
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

The kinase PI3K is crucial for insulin signalling in the liver but the roles of individual PI3K isoforms are largely unclear. Using mice that lack class II PI3K isoform γ (PI3K-C2γ), the authors here show that PI3K-C2γ selectively activates endosomal Akt2 by regulating the localized production of PIP2.

Laura Braccini
Elisa Ciraolo
Emilio Hirsch
ResearchOpen Access23 Jun 2015
Nature Communications

Volume: 6, P: 1-15
Rab5 regulates motility of early endosomes on microtubules

Erik Nielsen
Fedor Severin
Marino Zerial
Research16 Sept 1999
Nature Cell Biology

Volume: 1, P: 376-382
Substrate specificity: PI(3)Kγ has it both ways

Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)Kγ. Phosphorylation of tropomyosin is required for β-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.

Jonathan M. Backer
News & Views01 Aug 2005
Nature Cell Biology

Volume: 7, P: 773-774
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

Beclin 1 is an essential mediator of mammalian autophagy that has anti-tumour activity. Two proteins that interact with Beclin 1 have been newly identified and their analysis shows that distinct Beclin 1 complexes regulate autophagosome formation and maturation, respectively.

Yun Zhong
Qing Jun Wang
Zhenyu Yue
Research08 Mar 2009
Nature Cell Biology

Volume: 11, P: 468-476
Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract

Rupalatha Maddala
Junyuan Gao
Ponugoti V. Rao
ResearchOpen Access26 Jan 2021
Scientific Reports

Volume: 11, P: 1-16
Exposure science in an age of rapidly changing climate: challenges and opportunities

Judy S LaKind
Jonathan Overpeck
Benjamin C Blount
ReviewsOpen Access03 Aug 2016
Journal of Exposure Science & Environmental Epidemiology

Volume: 26, P: 529-538

Search

On the magnetization and origin of the millisecond pulsar 1937 + 214

Reconstitution of a phospholipid flippase from rat liver microsomes

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Defective acidification of intracellular organelles in cystic fibrosis

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

Suppression of an amber mutation by microinjection of suppressor tRNA in C. elegans

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Diminishing benefits of urban living for children and adolescents’ growth and development

Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost

Repositioning of the global epicentre of non-optimal cholesterol

Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences

Phosphatidylinositol-3-OH kinases are Rab5 effectors

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

Rab5 regulates motility of early endosomes on microtubules

Substrate specificity: PI(3)Kγ has it both ways

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract

Exposure science in an age of rapidly changing climate: challenges and opportunities

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