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Showing 1–6 of 6 results
Advanced filters: Author: Jongwon Im Clear advanced filters

  • Probiotic Escherichia coli Nissle 1917 is engineered as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays to safely induce specific, effective and durable systemic antitumour immunity.

    • Andrew Redenti
    • Jongwon Im
    • Nicholas Arpaia
    ResearchOpen Access
    Nature
    Volume: 635, P: 453-461

  • Uninterrupted monitoring of pressure and temperature at skin interfaces can help to minimize the potential for pressure injuries in hospitalized or bedridden patients. Here, the authors introduce a soft, skin-mountable sensor that can continuously provide readings via antennas mounted under bedding, and demonstrate the functionality and robustness of the devices on patients.

    • Yong Suk Oh
    • Jae-Hwan Kim
    • John A. Rogers
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • There is an unmet medical need for the detection and treatment of early adenomas to prevent their progression to malignant disease. Here the authors show that orally administered E. coli Nissle 1917 can selectively colonize adenomas in mouse models and in patients as a detection tool, as well as deliver immunotherapeutics for colorectal neoplasia treatment.

    • Candice R. Gurbatri
    • Georgette A. Radford
    • Tal Danino
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • A synthetic protein quality control system (ProQC) uses RNA hybridization to enhance translation of full-length proteins in coupled transcription–translation systems to optimize production of biosynthetic enzymes for metabolic engineering efforts.

    • Jina Yang
    • Yong Hee Han
    • Sang Woo Seo
    Research
    Nature Chemical Biology
    Volume: 17, P: 421-427

  • Bacteria-based living drugs can treat a broad range of diseases. This Review discusses challenges to the clinical translation of engineered bacterial therapeutics and how advances in synthetic biology and nanomedicine can help overcome them.

    • Jaeseung Hahn
    • Suwan Ding
    • Tal Danino
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 120-135