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Showing 1–3 of 3 results
Advanced filters: Author: Jonne L. Snitselaar Clear advanced filters

  • There are limited approaches to monitor virus spread in vivo. Here, the authors report PET/CT-based in vivo imaging to track SARS-CoV-2 biodistribution in a COVID-19 non-human primate model using a radiolabeled human antibody revealing persistent detection in the lung and brain 3 months after infection.

    • Alexandra Detrille
    • Steve Huvelle
    • Thibaut Naninck
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Monoclonal antibodies show great promise in treating Covid-19 patients. Here, Maisonnasse, Aldon and colleagues report pre-clinical results for COVA1-18 and demonstrate that it reduces viral infectivity in three animal models with over 95% efficacy in macaques upper respiratory tract.

    • Pauline Maisonnasse
    • Yoann Aldon
    • Roger Le Grand
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell repertoire, authors identify following infection, a subset of B cells enriched and almost exclusively target a non-neutralizing S2 epitope present in aberrant forms.

    • Mathieu Claireaux
    • Tom G. Caniels
    • Marit J. van Gils
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15