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Showing 1–2 of 2 results
Advanced filters: Author: Joo-Ran Kim Clear advanced filters

  • The GTPase eIF5B is involved in the correct positioning of the initiator Met-tRNAiMet on the ribosome during the late stages of translation initiation. Here the authors present a cryo-EM structure of the ribosome in complex with eIF5B and Met-tRNAiMet immediately before transition into elongation, providing insight on Met-tRNAiMetdelivery and how the correct reading frame is established.

    • Jinfan Wang
    • Jing Wang
    • Israel S. Fernández
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Eukaryotic initiation factor eIF2 binds initiator Met-tRNAiMet to the P site of the 40S ribosomal subunit. Hydroxyl radical probing analyses allowed mapping of the binding of eIF2 on the ribosome and on Met-tRNAiMet. Interestingly, despite having structural similarities to elongation factor EF-Tu, which delivers aminoacyl-tRNAs to the A site of 70S elongating ribosomes, eIF2 binds tRNA in a substantially different manner.

    • Byung-Sik Shin
    • Joo-Ran Kim
    • Thomas E Dever
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1227-1234