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Showing 1–12 of 12 results
Advanced filters: Author: Jorge Moscat Clear advanced filters

  • NF-κB is a critical transcription factor that is regulated by several post-transcriptional modifications. The characterization of their roles would help in the design of new therapeutic targets in cancer and inflammation.

    • Jorge Moscat
    • Maria T Diaz-Meco
    News & Views
    Nature Immunology
    Volume: 12, P: 12-14

  • The transition of androgen receptor-dependent prostate cancer to a therapy resistant cancer with neuroendocrine phenotype is an important process that remains poorly understood. Here, the authors show that PKCλ/ι-loss promotes epigenetic reprogramming resulting in a TGFβ resistance programme via transcriptional upregulation of translational machinery.

    • Shankha S. Chatterjee
    • Juan F. Linares
    • Maria T. Diaz-Meco
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • The underlying mechanisms driving colorectal cancer (CRC) through the serrated route are largely unknown. Here, the authors show that reduced aPKC levels increase cholesterol biosynthesis to promote aggressiveness in serrated tumours and targeting this pathway reduces tumourigenesis in preclinical models of serrated CRC.

    • Yu Muta
    • Juan F. Linares
    • Jorge Moscat
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Thrombospondin-1 (THBS1) is a matricellular protein highly expressed in inflammatory processes, including cancer. Here the authors show that bone-marrow derived monocyte-like cells are the primary source of THBS1 in colorectal cancer, associated with mesenchymal characteristics, immunosuppression and a poor prognosis.

    • Mayuki Omatsu
    • Yuki Nakanishi
    • Hiroshi Seno
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • p62 is a signaling hub protein that contributes to the control of energy expenditure. Here the authors investigate the relative roles of p62 and a similar protein, NBR1, and show that NBR1 is required for the repression of thermogenesis in adipocytes occurring in the absence of p62.

    • Jianfeng Huang
    • Juan F. Linares
    • Jorge Moscat
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates brown adipose tissue function through modifying ATF2 genomic binding and subsequent Ucp1 and Pgc-1α induction.

    • Katrin Fischer
    • Anna Fenzl
    • Timo D. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Fructose consumption has greatly increased in recent years and has been linked to the development of hepatic steatosis. Here, the authors show that fructose promotes gut-barrier deterioration and subsequent endotoxaemia that in turn induces hepatic lipogenesis by activation TLR signalling in liver macrophages.

    • Jelena Todoric
    • Giuseppe Di Caro
    • Michael Karin
    Research
    Nature Metabolism
    Volume: 2, P: 1034-1045

  • The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.

    • Yi Zhang
    • Su Ran Mun
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Efforts to identify new therapeutic targets in cancer primarily focused on oncogenes and tumor suppressor genes, and their mechanisms of action. However, there is an emerging alternative strategy that involves identification of target proteins that are not encoded by oncogenes, but are, nonetheless, required to accommodate cancer-specific stresses.

    • Jorge Moscat
    • Adam Richardson
    • Maria T Diaz-Meco
    Research Highlights
    Cell Research
    Volume: 25, P: 537-538