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Showing 1–6 of 6 results
Advanced filters: Author: Jorja G Henikoff Clear advanced filters

  • Conducting epigenomic studies on FFPE samples is traditionally challenging due to chromatin damage caused due to exposure to formaldehyde. Here, the authors show that an optimisation of their previous CUTAC method allows the production of high-resolution maps of regulatory elements from FFPE samples.

    • Steven Henikoff
    • Jorja G. Henikoff
    • Eric C. Holland
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Understanding gene regulation will require mapping specific chromain features in a small number of cells at high resolution. Here the authors describe CUT&Tag, which uses antibody-mediated tethering of Tn5 transposase to a chromatin protein to generate high resolution libraries.

    • Hatice S. Kaya-Okur
    • Steven J. Wu
    • Steven Henikoff
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • The authors describe a streamlined epigenomic profiling protocol based on cut-and-paste tagmentation by the Tn5 transposase targeted to a chromatin protein of interest.

    • Hatice S. Kaya-Okur
    • Derek H. Janssens
    • Steven Henikoff
    Protocols
    Nature Protocols
    Volume: 15, P: 3264-3283

  • Nucleosomes consist of two copies of each histone. H2A.Z is a variant H2A-related histone known to be enriched around transcription start sites. However, an H2A.Z-containing nucleosome could contain contain two copies of H2A.Z (homotypic) or one of H2A.Z and one of canonical H2A (heterotypic). Homotypic and heterotypic H2A.Z nucleosomes are now mapped and their distributions relative to promoters analyzed.

    • Christopher M Weber
    • Jorja G Henikoff
    • Steven Henikoff
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1500-1507