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Showing 1–3 of 3 results
Advanced filters: Author: Jory Goldsmith Clear advanced filters

  • The opening mechanism of the SARS-CoV-2 spike protein has been studied by integrating computational and experimental data. Combining weighted ensemble molecular dynamics simulations, biolayer interferometry and ManifoldEM analysis of cryo-EM data revealed that the glycan at N343 plays a gating role in the opening mechanism of the SARS-CoV-2 spike protein.

    • Terra Sztain
    • Surl-Hee Ahn
    • Rommie E. Amaro
    Research
    Nature Chemistry
    Volume: 13, P: 963-968

  • The authors present a protocol for expressing and biophysically characterizing rationally engineered SARS-CoV-2 spike proteins in Freestyle 293 and ExpiCHO cell lines.

    • Jeffrey M. Schaub
    • Chia-Wei Chou
    • Ilya J. Finkelstein
    Protocols
    Nature Protocols
    Volume: 16, P: 5339-5356

  • In order to examine the role of the circadian clock driver Brain and Muscle ARNT-Like 1 (Bmal1) in alcohol consumption, de Zavalia et al assess the effects of (Bmal1) deletion in the mouse striatum on alcohol drinking behavior. They show that striatal Bmal1 and downstream effects on Period Circadian Regulator 2 (Per2) play a sex-dependent role on alcohol consumption propensity.

    • Nuria de Zavalia
    • Konrad Schoettner
    • Shimon Amir
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13